Viral infection

Definition

Viral infection is the invasion of the body by a small agent known as a virus. Viruses replicate inside host cells and can produce toxins that cause disease. The immune system helps to destroy viruses, but antiviral immune responses can also cause tissue damage and illness.

Latest Research and Reviews

News and Comment

  • News and Views |

    Dysfunctional immunity is associated with dengue hemorrhagic fever and dengue shock syndrome. Structural analyses reveal that a key germline-encoded contact between the T cell antigen receptor and a peptide underpins the immunodominance of dengue-virus-specific CD8+ T cell responses of weak affinity.

    • Sydney Blevins
    •  & Eric S Huseby
    Nature Immunology 18, 1186–1188
  • Research Highlights |

    In a recent study, Takata et al. show that viral CG suppression is key for the replication of HIV-1 and that the zinc-finger antiviral protein (ZAP), by specifically binding to CG-rich RNA sequences, can identify non-self RNAs and target them for degradation.

    • Irene Vacca
  • News and Views |

    The 2013–2016 West African Ebola virus outbreak evidenced that the virus can persist in survivors long-term, leading to sequelae and risks of new transmission chains. Ebola virus has now been shown to behave similarly in rhesus macaques, enabling their use to study persistence and intervention strategies.

    • Trina Racine
    •  & Gary P. Kobinger