Featured
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Article
| Open Access
Bacteriophages suppress CRISPR–Cas immunity using RNA-based anti-CRISPRs
In response to bacterial CRISPR–Cas immunity, phages and plasmids have evolved small non-coding RNA anti-CRISPRs, known as Racrs, that sequester Cas proteins in abberrant complexes and thereby inhibit immunity.
- Sarah Camara-Wilpert
- , David Mayo-Muñoz
- & Rafael Pinilla-Redondo
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Article
| Open Access
Mirusviruses link herpesviruses to giant viruses
A phylogeny-guided genome-resolved metagenomic analysis of DNA viruses in the ocean reveals atypical plankton-infecting relatives of herpesviruses that form a putative new phylum dubbed Mirusviricota.
- Morgan Gaïa
- , Lingjie Meng
- & Tom O. Delmont
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Article |
Adeno-associated virus 2 infection in children with non-A–E hepatitis
A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.
- Antonia Ho
- , Richard Orton
- & Emma C. Thomson
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Review Article |
Unconventional viral gene expression mechanisms as therapeutic targets
This Review outlines the gene and protein expression strategies used by viruses to expand the efficiency of their coding and regulatory sequences, and the implications of these mechanisms for developing antiviral agents.
- Jessica Sook Yuin Ho
- , Zeyu Zhu
- & Ivan Marazzi
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Letter |
Genomic epidemiology reveals multiple introductions of Zika virus into the United States
Genome sequencing of Zika virus samples from infected patients and Aedes aegypti mosquitoes in Florida shows that the virus was probably introduced into the United States on multiple occasions, and that the Caribbean is the most likely source.
- Nathan D. Grubaugh
- , Jason T. Ladner
- & Kristian G. Andersen
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Letter |
Viral immune modulators perturb the human molecular network by common and unique strategies
A systems approach provides a global perspective of the different strategies that viruses use to modulate the cellular innate immune response; this may be useful in the design of future viral intervention strategies.
- Andreas Pichlmair
- , Kumaran Kandasamy
- & Giulio Superti-Furga
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News & Views |
Influenza's tale of tails
Epigenetics is a hot new research field, but it seems that the influenza virus already has it figured out. By mimicking epigenetic regulation in human cells, one flu strain suppresses the expression of antiviral genes. See Article p.428
- Alexei L. Krasnoselsky
- & Michael G. Katze
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Outlook |
Morbidity: A personal response
Some people get horribly sick from the flu, and even die. Others just rest for a few days. What's behind this fateful variation?
- Christine Junge
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News & Views |
One protein, many functions
The Lassa virus nucleoprotein coats the viral genome to make a template for RNA synthesis. A study shows that it also binds the 'cap' structure of cellular messenger RNAs and directs immune evasion using a novel mechanism. See Article p.779
- Félix A. Rey
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Research Highlights |
Virology: Back-up resistance
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Article |
Retroviral intasome assembly and inhibition of DNA strand transfer
The integrase protein of retroviruses such as HIV-1 catalyses insertion of the viral genome into that of the host. Here, the long-awaited structure of the full-length integrase complex is predicted, revealing not only details of the biochemistry of the integration reaction, but also the means by which current inhibitors affect this process.
- Stephen Hare
- , Saumya Shree Gupta
- & Peter Cherepanov
Phages overcome bacterial immunity via diverse anti-defence proteins