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The vestibuloocular reflex (VOR) is a compensatory process by which the eyes move in the opposite direction to that of the head, stabilizing the retinal image of a visual target. The VOR is driven primarily by the vestibular system.
Global mapping shows that mouse retinal neurons prefer visual motion
produced when the animal moves along two behaviourally relevant axes, allowing the
encoding of the animal’s every translation and rotation.
The extent to which non-cerebellar pathways can refine motor performance is debated. Here, the authors demonstrate behaviourally relevant patterns of activation evoke rapid plasticity within direct and indirect vestibulo-ocular reflex pathways in vivo, leading to changes in evoked eye movements.
Processing multiple sensory modalities is critical for executing complex behaviors. This study finds that single cerebellar granule cells integrate inputs from both vestibular and visual input pathways, each exhibiting characteristic synaptic strengths and plasticities. These are translated into output dynamics that enhance the network's representation of complex sensory contexts.
Theory suggests that cerebellar granule cells combine sensory and motor signals originating from different sources. An unexpected logic governing how granule cells process different input sources may enhance computational power.