Ubiquitylation is the post-translational modification process by which ubiquitin is attached via an isopeptide bond to lysine residues on a protein. Ubiquitylation consists of three steps, activation by ubiquitin-activating enzymes (E1 enzymes), conjugation by ubiquitin-conjugating enzymes (E2s) and attachment to the substrate protein by ubiquitin ligases (E3s).
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