Translational immunology

Translational immunology is the process by which researchers use immunological discoveries to develop practical solutions for human problems. Examples include the development of vaccines against infectious diseases or the engineering of new types of drugs to treat inflammatory disorders.

Latest Research and Reviews

  • Research |

    Ageing is associated with deteriorating immune function and metabolic diseases. Here, the authors show that plasma levels of the stress-response protein MANF decline with age in various organisms and that MANF has beneficial effects on immune and metabolic function, particularly in the liver, in old mice.

    • Pedro Sousa-Victor
    • , Joana Neves
    • , Wendy Cedron-Craft
    • , P. Britten Ventura
    • , Chen-Yu Liao
    • , Rebeccah R. Riley
    • , Ilya Soifer
    • , Nicholas van Bruggen
    • , Ganesh A. Kolumam
    • , Saul A. Villeda
    • , Deepak A. Lamba
    •  & Heinrich Jasper
    Nature Metabolism 1, 276-290
  • Research | | open

    Tr1 cells are considered an immunosuppressive CD4 T cell population producing IL-10. Here the authors show that IL-10 is insufficient for Tr1 immunosuppression, define surface markers and transcriptional program of the immunosuppressive subset within Tr1, and reveal its deficiency in patients with IBD.

    • Leonie Brockmann
    • , Shiwa Soukou
    • , Babett Steglich
    • , Paulo Czarnewski
    • , Lilan Zhao
    • , Sandra Wende
    • , Tanja Bedke
    • , Can Ergen
    • , Carolin Manthey
    • , Theodora Agalioti
    • , Maria Geffken
    • , Oliver Seiz
    • , Sara M. Parigi
    • , Chiara Sorini
    • , Jens Geginat
    • , Keishi Fujio
    • , Thomas Jacobs
    • , Thomas Roesch
    • , Jacob R. Izbicki
    • , Ansgar W. Lohse
    • , Richard A. Flavell
    • , Christian Krebs
    • , Jan-Ake Gustafsson
    • , Per Antonson
    • , Maria Grazia Roncarolo
    • , Eduardo J. Villablanca
    • , Nicola Gagliani
    •  & Samuel Huber
  • Research | | open

    Mutations within immunological epitope containing regions of influenza A virus can impair the established immune response between influenza strains and could impact rational vaccine design. Here Grant et al. examine the presence, structural impact and cross reactivity of two human immunodominant influenza epitope variants.

    • Emma J. Grant
    • , Tracy M. Josephs
    • , Liyen Loh
    • , E. Bridie Clemens
    • , Sneha Sant
    • , Mandvi Bharadwaj
    • , Weisan Chen
    • , Jamie Rossjohn
    • , Stephanie Gras
    •  & Katherine Kedzierska
  • Research | | open

    Niewold, Cohen et al. identify Ly6Clo monocytes as a major component of immune cell sequestration in a mouse model of severe malaria. They show that combined immune-modifying particles and anti-malarial drug treatment at the onset of disease signs results in 88% survival of malaria-infected mice.

    • Paula Niewold
    • , Amy Cohen
    • , Caryn van Vreden
    • , Daniel R. Getts
    • , Georges E. Grau
    •  & Nicholas J. C. King
  • Research | | open

    Antigen present and presented in the structures of the skin can result in immune responses that elicit tolerance, protective immunity or allergy, depending on the immunological context. Here the authors describe a key role for the hair follicle and CD11b+ dendritic cells in the priming of local antigenic tolerance.

    • Leticia Tordesillas
    • , Daniel Lozano-Ojalvo
    • , David Dunkin
    • , Lucie Mondoulet
    • , Judith Agudo
    • , Miriam Merad
    • , Hugh A. Sampson
    •  & M. Cecilia Berin

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