Featured
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Research Highlight |
FlipFlop of the T cell immune system
FlipFlop mice harbor functionally reversed T cells due to a switch in CD4 and CD8 expression.
- Nina Vogt
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Research Highlight |
Jellyfish enter neuroscience research
Jellyfish are established as a model system for neuroscience.
- Nina Vogt
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Tools in Brief |
One mouse to trap them all
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Article |
Rapidly evolving homing CRISPR barcodes
Homing guide RNAs that target Cas9 to their own loci generate diverse barcodes that can trace the lineage of cells.
- Reza Kalhor
- , Prashant Mali
- & George M Church
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Brief Communication |
A naturally monomeric infrared fluorescent protein for protein labeling in vivo
An infrared fluorescent protein based on a new monomeric scaffold is described in this paper and is tested for protein fusion in cells and in vivo.
- Dan Yu
- , Michelle A Baird
- & Xiaokun Shu
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Tools in Brief |
Inducing CRISPR
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Tools in Brief |
A Cas9 knock-in mouse
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Research Highlights |
Targeted nucleases fight malaria
Genome engineering skews the sex ratio of malaria-carrying mosquitoes heavily toward males and leads to a population crash.
- Nicole Rusk
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Research Highlights |
A tool belt for GFP
Nanobodies turn any GFP-expressing cells into targets for in vivo functional manipulation.
- Tal Nawy
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Tools in Brief |
GCaMP transgenic mice
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Tools in Brief |
More optogenetic mouse lines
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Article |
Antiviral restriction factor transgenesis in the domestic cat
This paper reports transgenesis by genetic modification of gametes in the domestic cat. The approach is used to generate transgenic cats expressing a virus restriction factor from rhesus macaque.
- Pimprapar Wongsrikeao
- , Dyana Saenz
- & Eric Poeschla
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Research Highlights |
Speeding up RNAi
A recent study turns the creation of conditional short hairpin RNA transgenic mice into a rapid, flexible and scalable process.
- Erika Pastrana
Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression