Thrombotic microangiopathies

Definition

Thrombotic microangiopathies are a group of diseases caused by thrombosis in the microvasculature, they most frequently affect the brain and kidneys. Two prominent causes are thrombotic thrombocytopenic purpura and haemolytic uremic syndrome.

Latest Research and Reviews

  • Reviews |

    Scleroderma renal crisis is a rare, potentially life-threatening complication of systemic sclerosis. Here, the authors discuss advances made in the detection, management and prognosis of scleroderma renal crisis, which can limit the progression of affected patients to chronic kidney disease.

    • Thasia G. Woodworth
    • , Yossra A. Suliman
    • , Daniel E. Furst
    •  & Philip Clements
  • Reviews |

    Autoantibodies against complement factor H (FH), the main plasma regulatory protein of the alternative pathway of the complement system, are associated with atypical haemolytic uraemic syndrome and C3 glomerulopathy. Here, Arvind Bagga and colleagues describe the prevalence, mechanisms, features, therapies and outcomes of kidney diseases mediated by anti-FH antibodies, and propose an approach to evaluate and manage these diseases.

    • Marie-Agnes Dragon Durey
    • , Aditi Sinha
    • , Shambhuprasad Kotresh Togarsimalemath
    •  & Arvind Bagga
  • Reviews |

    Disseminated intravascular coagulation can be caused by various infectious and non-infectious insults, such as sepsis and trauma, respectively. It is characterized by the widespread activation of coagulation and, depending on the underlying condition, can manifest as bleeding and/or thrombosis.

    • Satoshi Gando
    • , Marcel Levi
    •  & Cheng-Hock Toh
  • Reviews |

    The functions of the complement system are diverse and extend beyond its role in host defence; complement activation is now known to contribute to numerous immunological, inflammatory and age-related conditions, including kidney disorders. Here, John Lambris and colleagues discuss the key activating, regulatory, and effector mechanisms of the complement system. They highlight important crosstalk connections with other regulatory systems, and, with a focus on kidney disease and transplantation, describe the involvement of complement in clinical conditions as well as promising therapeutic approaches.

    • Daniel Ricklin
    • , Edimara S. Reis
    •  & John D. Lambris
  • Reviews |

    Renal transplantation is the optimal form of renal replacement therapy for children with end-stage renal disease; however, disease recurrence can lead to graft loss, morbidity and death. In this Review, Justine Bacchetta and Pierre Cochat provide an update on the epidemiology, pathophysiology, effects and management of disease recurrence after paediatric renal transplantation. They also describe pretransplantation and post-transplantation risk-reduction strategies that aim to minimize the possibility of disease recurrence, and thus improve both graft and patient outcomes.

    • Justine Bacchetta
    •  & Pierre Cochat

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