News & Views |
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Article |
Photo-expansion microscopy enables super-resolution imaging of cells embedded in 3D hydrogels
Photopolymerizable hydrogels enable optical clearance and high homogeneous expansion for high-resolution optical imaging of cells embedded within degradable hydrogels.
- Kemal Arda Günay
- , Tze-Ling Chang
- & Kristi S. Anseth
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Article |
A mechano-signalling network linking microtubules, myosin IIA filaments and integrin-based adhesions
Crosstalk between microtubules and the actin cytoskeleton of cells is important in elucidating integrin-mediated adhesion and mechanotransduction. It is now shown that microtubule-mediated control of focal adhesions and podosomes occurs via KANK family proteins.
- Nisha Bte Mohd Rafiq
- , Yukako Nishimura
- & Alexander D. Bershadsky
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Letter |
A super-oscillatory lens optical microscope for subwavelength imaging
The maximum imaging resolution in classical optics is limited to approximately the wavelength of light used, and subwavelength resolution can only be achieved by advanced imaging schemes. The appeal of the super-oscillatory lens optical microscope described here is that it enables subwavelength imaging with, in principle, unlimited resolution using a modified conventional microscope.
- Edward T. F. Rogers
- , Jari Lindberg
- & Nikolay I. Zheludev
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News & Views |
A crystal-clear view
The mechanisms of biomineralization remain hotly debated. Now high-resolution microscopy yields unsurpassed insight into mechanisms relevant both to the biomineralization of bone and teeth and to pathological mineralization.
- Helmut Cölfen
A thicker skin for better immune evasion