Stem-cell niche

Definition

A stem-cell niche is an area of a tissue that provides a specific microenvironment, in which stem cells are present in an undifferentiated and self-renewable state. Cells of the stem-cell niche interact with the stem cells to maintain them or promote their differentiation.

Latest Research and Reviews

  • Research | | open

    Limb regeneration requires a blastema with progenitor cells, immune cells, and an overlying wound epidermis, but molecular identities of these populations are unclear. Here, the authors use single-cell RNA-sequencing to identify transcriptionally distinct cell populations in adult axolotl limb blastemas.

    • Nicholas D. Leigh
    • , Garrett S. Dunlap
    • , Kimberly Johnson
    • , Rachelle Mariano
    • , Rachel Oshiro
    • , Alan Y. Wong
    • , Donald M. Bryant
    • , Bess M. Miller
    • , Alex Ratner
    • , Andy Chen
    • , William W. Ye
    • , Brian J. Haas
    •  & Jessica L. Whited
  • Research |

    In zebrafish embryogenesis, nascent haematopoietic stem and progenitor cells (HSPCs), homing to a vascular niche for retention, are ushered by patrolling and guiding macrophages through integrin-mediated cell-cell recognition.

    • Dantong Li
    • , Wenzhi Xue
    • , Mei Li
    • , Mei Dong
    • , Jianwei Wang
    • , Xianda Wang
    • , Xiyue Li
    • , Kai Chen
    • , Wenjuan Zhang
    • , Shuang Wu
    • , Yingqi Zhang
    • , Lei Gao
    • , Yujie Chen
    • , Jianfeng Chen
    • , Bo O. Zhou
    • , Yi Zhou
    • , Xuebiao Yao
    • , Lin Li
    • , Dianqing Wu
    •  & Weijun Pan
    Nature 564, 119–124
  • Research | | open

    Leydig cells are steroidogenic cells in the testes and produce the androgens required for male development and spermatogenesis. Here the authors show that a multipotent progenitor population producing Leydig cells, pericytes and smooth muscle cells is maintained in a perivascular niche within the mouse fetal testis.

    • Deepti L. Kumar
    •  & Tony DeFalco
  • Research | | open

    Self-renewal of spermatogonial stem cells (SSC) is necessary for spermatogenesis and male fertility. Here the authors identify testicular endothelial cells (TECs) as a source of 5 key growth factors for self-renewal and expansion of human and mouse SSCs.

    • Dong Ha Bhang
    • , Bang-Jin Kim
    • , Byung Gak Kim
    • , Keri Schadler
    • , Kwan-Hyuck Baek
    • , Yong Hee Kim
    • , Wayland Hsiao
    • , Bi-Sen Ding
    • , Shahin Rafii
    • , Mitchell J. Weiss
    • , Stella T. Chou
    • , Thomas F. Kolon
    • , Jill P. Ginsberg
    • , Buom-Yong Ryu
    •  & Sandra Ryeom
  • Research | | open

    • Jingtao Guo
    • , Edward J. Grow
    • , Hana Mlcochova
    • , Geoffrey J. Maher
    • , Cecilia Lindskog
    • , Xichen Nie
    • , Yixuan Guo
    • , Yodai Takei
    • , Jina Yun
    • , Long Cai
    • , Robin Kim
    • , Douglas T. Carrell
    • , Anne Goriely
    • , James M. Hotaling
    •  & Bradley R. Cairns
    Cell Research 28, 1141–1157

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