Stem-cell niche articles within Nature Materials

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• Review Article | 16 November 2020

  Rethinking organoid technology through bioengineering

  This Review provides an overview of bioengineering technologies that can be harnessed to facilitate the culture, self-organization and functionality of human pluripotent stem cell-derived organoids.

  • Elena Garreta
  • , Roger D. Kamm
  •  & Nuria Montserrat

• Letter | 12 December 2016

  Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche

  The control of biophysical cues during the culture of human pluripotent stem cells on biomaterial substrates can be used to replicate the in vivo amniogenic environment and direct in vitro generation of early human amniotic tissue.

  • Yue Shao
  • , Kenichiro Taniguchi
  •  & Jianping Fu

• Article | 15 August 2016

  N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells

  N-cadherin can alter how the stiffening extracellular microenvironment is interpreted by mesenchymal stem cells, leading to subsequent changes in downstream cell proliferation and differentiation.

  • Brian D. Cosgrove
  • , Keeley L. Mui
  •  & Robert L. Mauck

• Commentary | 21 May 2014

  Combining insoluble and soluble factors to steer stem cell fate

  Materials-based control of stem cell fate is beginning to be rigorously combined with traditional soluble-factor approaches to better understand the cells' behaviour and maximize their potential for therapy.

  • P. C. Dave P. Dingal
  •  & Dennis E. Discher