Spermatogenesis articles within Nature Communications

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  • Article
    | Open Access

    Sperm from aging males may decline in quality, but it is unclear how aging affects the ability of males to produce successful offspring. Here, the authors show that paternal aging of captive long-lived houbara bustards reduces both the likelihood that eggs hatch and the rate at which chicks grow.

    • Brian T. Preston
    • , Michel Saint Jalme
    •  & Gabriele Sorci

  • Article |

    As the fertility of pre-pubertal male patients undergoing chemotherapy cannot be preserved using semen cryopreservation, alternative approaches are needed. Here the authors generate live mouse offspring via assisted reproduction technologies, using round spermatids or sperm derived from neonatal mouse cryopreserved testis tissues.

    • Tetsuhiro Yokonishi
    • , Takuya Sato
    •  & Takehiko Ogawa

  • Article |

    Somatic histones are replaced with sperm-specific basic proteins, called protamines, during the chromatin remodelling phase of spermatogenesis. Here, the authors show that the chromatin remodelling protein Chd5 is required for histone-to-protamine replacement during spermatogenesis in mice.

    • Wangzhi Li
    • , Jie Wu
    •  & Alea A. Mills

  • Article |

    Changes in DNA methylation during mammalian spermatogenesis are poorly understood. The authors show that the content of 5-hydroxymethylcytosine, a stable intermediate of DNA demethylation, changes dynamically during mouse spermatogenesis and is associated with functional genomic regions and transcription.

    • Haiyun Gan
    • , Lu Wen
    •  & Fuchou Tang

  • Article |

    The temporal opening and closing of cell–cell junctions at the blood–testis barrier allows the passage of immature germ cells during spermatogenesis. Su and colleagues identify a peptide fragment of the laminin-γ3 chain that disrupts the blood–testis barrier and reversibly impairs spermatogenesis in rats.

    • Linlin Su
    • , Dolores D. Mruk
    •  & C. Yan Cheng

  • Article |

    Recent technological advances have allowed the expansion of spermatogonial stem cellsin vitro; however, in vivo conditions are required for the full differentiation of the cells. In this study, an in vitroorgan culture system is developed that allows the differentiation of the germ cells in the laboratory.

    • Takuya Sato
    • , Kumiko Katagiri
    •  & Takehiko Ogawa

  • Article |

    Some organisms produce unequal numbers of male and female progeny, but the mechanics of skewed of sex ratios are largely unknown. Here, the authors describe alterations in X-chromosome segregation and cytoplasmic partitioning during spermatogenesis that together explain the distorted sex ratio in a nematode species.

    • Diane C. Shakes
    • , Bryan J. Neva
    •  & Andre Pires-daSilva

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