Solid-state NMR

Solid-state nuclear magnetic resonance (ssNMR) spectroscopy is a variant of the NMR spectroscopy technique used for molecular structure determination, where the experimental sample is contained in media with little or no mobility (such as, a crystalline or powder state, membrane-bound system or aligned solution).

Latest Research and Reviews

  • Research | | open

    The halogen bond is well known for its ability to assemble supramolecules. Here, using NMR experiments, the authors reveal the role of these bonds in dynamic processes, finding that the halogen bond directly catalyzes dynamical rotation in solid cocrystals by reducing the associated energy barrier.

    • Patrick M. J. Szell
    • , Scott Zablotny
    •  & David L. Bryce
  • Research | | open

    The interactions of lignin with polysaccharides in plant secondary cell walls are not well understood. Here the authors employ solid-state NMR measurements to analyse intact stems of maize, Arabidopsis, switchgrass and rice and observe that lignin self-aggregates and forms highly hydrophobic microdomains that make extensive surface contacts to xylan.

    • Xue Kang
    • , Alex Kirui
    • , Malitha C. Dickwella Widanage
    • , Frederic Mentink-Vigier
    • , Daniel J. Cosgrove
    •  & Tuo Wang
  • Research | | open

    Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels are caused by large shifts in the channel dynamics which perturb the selectivity filter.

    • Shehrazade Jekhmane
    • , João Medeiros-Silva
    • , Jing Li
    • , Felix Kümmerer
    • , Christoph Müller-Hermes
    • , Marc Baldus
    • , Benoît Roux
    •  & Markus Weingarth
  • Research | | open

    Impaired kidney function can lead to an increase of β2-microglobulin (β2m) serum levels, which can cause β2m aggregation and amyloid fibril formation. Here the authors combine cryo-EM and magic angle spinning NMR measurements to determine the structure of a β2m fibril and they also present the low resolution model of a β2m fibril with a different morphology.

    • Matthew G. Iadanza
    • , Robert Silvers
    • , Joshua Boardman
    • , Hugh I. Smith
    • , Theodoros K. Karamanos
    • , Galia T. Debelouchina
    • , Yongchao Su
    • , Robert G. Griffin
    • , Neil A. Ranson
    •  & Sheena E. Radford
  • Research | | open

    Fast oxide ion conductors are the key materials for some technological devices. Here the authors report the creation and stabilization of oxygen vacancies in BiVO4 Scheelite with isolated tetrahedral anion structures for improved ionic conducting performance and understanding of the conduction mechanism.

    • Xiaoyan Yang
    • , Alberto J. Fernández-Carrión
    • , Jiehua Wang
    • , Florence Porcher
    • , Franck Fayon
    • , Mathieu Allix
    •  & Xiaojun Kuang
  • Research | | open

    Binding of bacterial peptidoglycan muramyl dipeptides induces NOD2 activation and signalling via the downstream adaptor kinase RIP2. Here the authors show that RIP2 forms filaments via its CARD domain, analyse the structure of the CARD filaments and demonstrate the requirement of RIP2 polymerisation for the activation of NF-κB by NOD2.

    • Erika Pellegrini
    • , Ambroise Desfosses
    • , Arndt Wallmann
    • , Wiebke Manuela Schulze
    • , Kristina Rehbein
    • , Philippe Mas
    • , Luca Signor
    • , Stephanie Gaudon
    • , Grasilda Zenkeviciute
    • , Michael Hons
    • , Helene Malet
    • , Irina Gutsche
    • , Carsten Sachse
    • , Guy Schoehn
    • , Hartmut Oschkinat
    •  & Stephen Cusack

News and Comment

  • News and Views |

    Sporopollenin, which encapsulates gametes in spore and pollen grains, is probably the most chemically inert biopolymer. This inertness is essential for gamete protection, but also hinders the elucidation of sporopollenin molecular structure. Now, the macromolecular network forming sporopollenin is described in unprecedented detail.

    • Paula Guzmán-Delgado
    •  & Maciej A. Zwieniecki
  • News and Views |

    Generating pure spin currents is a necessary part of many spintronic devices. Now there is a new mechanism for doing this, utilizing nuclear spin waves.

    • Claudia K. A. Mewes
    Nature Physics 15, 8-9
  • Editorial |

    In a common yet effective analogy, a cell can be compared to a fortified city, in which lipid membranes form the defensive walls, and membrane proteins function as gates and checkpoints that control the transit of molecules and information across these walls. We evoke this concept on the cover of this special Focus on Membrane Proteins.

  • News and Views |

    All current evidence indicates a central role for α-synuclein (α-SYN) amyloid fibrils in Parkinson's disease and other synucleinopathies, but the precise relationship between amyloid aggregates and the resulting phenotype remains poorly understood, partly because of the lack of reliable three-dimensional structures. In this issue, the structure of a toxic α-SYN fibril is now presented at unprecedented resolution.

    • Wouter Peelaerts
    •  & Veerle Baekelandt