Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Recent advances in scanning probe-based tomographic imaging have greatly improved spatial resolution, but systematic and random errors are a serious impediment to reliable data extraction. Here, a combined optimization and alignment algorithm provides a scalable approach to error-correcting reconstruction of large datasets.