Sleep deprivation articles within Nature Communications

Featured

• Article
  01 December 2023 | Open Access

  Opposing brain signatures of sleep in task-based and resting-state conditions

  The associations between sleep, depression and brain activity are not well understood. Here, the authors show patterns of brain activity associated with insomnia and depression resemble those found in people who sleep less, but only under cognitive load. At rest, these activation patterns are hyperconnected and resemble those found in longer sleepers.

  • Mohamed Abdelhack
  • , Peter Zhukovsky
  •  & Daniel Felsky

• Article
  04 November 2023 | Open Access

  Spatial transcriptomics reveals unique gene expression changes in different brain regions after sleep deprivation

  Sleep deprivation impacts molecular changes across brain regions. Here, the authors utilize a spatial. transcriptomics approach to elucidate acute sleep deprivation-induced gene expression signature. across regions and subregions of the brain.

  • Yann Vanrobaeys
  • , Zeru J. Peterson
  •  & Ted Abel

• Article
  30 April 2021 | Open Access

  Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia

  Cardiac function fluctuates greatly across the day and night, but this is not simply a consequence of our changing behaviour. The authors highlight the role of the body’s circadian clock in regulating the heart electrical activity, including a time-of-day dependent susceptibility to cardiac arrhythmias.

  • Edward A. Hayter
  • , Sophie M. T. Wehrens
  •  & David A. Bechtold

• Article
  14 August 2018 | Open Access

  Sleep loss causes social withdrawal and loneliness

  Loneliness markedly increases mortality and morbidity, yet the factors triggering loneliness remain largely unknown. This study shows that sleep loss leads to a neurobehavioral phenotype of human social separation and loneliness, one that is transmittable to non-sleep-deprived individuals.

  • Eti Ben Simon
  •  & Matthew P. Walker

• Article
  17 October 2016 | Open Access

  Stereotypic wheel running decreases cortical activity in mice

  Sleep need is thought to accumulate gradually over waking periods and is associated with changes in neuronal activity. Here the authors show that in mice cortical firing rates increase between the beginning and end of wakefulness periods but this increase is not seen in waking periods with voluntary stereotypic wheel running.

  • Simon P. Fisher
  • , Nanyi Cui
  •  & Vladyslav V. Vyazovskiy

• Article | 14 October 2015

  Sleep disruption impairs haematopoietic stem cell transplantation in mice

  How can you increase the success of hematopoietic stem cell (HSC) transplantation? In mice, Rolls et al. identify sleep in the donor as an important factor, finding that less sleep leads to 50% lower HSC engraftment, via miR-19b and suppressor of cytokine signaling genes, which prevent HSC homing.

  • Asya Rolls
  • , Wendy W. Pang
  •  & Luis de Lecea

• Article | 06 August 2013

  The impact of sleep deprivation on food desire in the human brain

  Insufficient sleep is a known risk factor for obesity. Greeret al.show that sleep deprivation amplifies mesolimbic brain responses to food stimuli, yet impairs activity in higher cortical areas, which, together, are associated with an increased desire for high-calorie food items.

  • Stephanie M. Greer
  • , Andrea N. Goldstein
  •  & Matthew P. Walker