Single-channel recording articles within Nature Communications

Featured

• Article
  20 June 2022 | Open Access

  Mapping the conformational energy landscape of Abl kinase using ClyA nanopore tweezers

  Quantitative characterization of kinase conformational dynamics remains challenging. Here, the authors show that protein nanopore tweezers allow analyzing the conformational energy landscape and ligand binding of the Abl kinase domain.

  • Fanjun Li
  • , Monifa A. Fahie
  •  & Min Chen

• Article
  22 March 2022 | Open Access

  Spelling interface using intracortical signals in a completely locked-in patient enabled via auditory neurofeedback training

  The authors record neural firing rates in a patient with ALS in completely locked-in state and show that the patient can modulate neural firing rates based on auditory feedback to select letters to form words and phrases to communicate his needs and experiences.

  • Ujwal Chaudhary
  • , Ioannis Vlachos
  •  & Niels Birbaumer

• Article
  15 September 2021 | Open Access

  Structural determinants and regulation of spontaneous activity in GABA_A receptors

  GABA_A receptors (GABA_ARs) cause inhibition in the brain by functioning as heteropentamers formed from multiple subunit types. Here, the authors demonstrate that receptors incorporating β3 subunits can spontaneously gate, which is modulated by protein kinases and neurosteroids to affect tonic inhibition.

  • Craig A. Sexton
  • , Reka Penzinger
  •  & Trevor G. Smart

• Article
  05 February 2021 | Open Access

  Pathological conformations of disease mutant Ryanodine Receptors revealed by cryo-EM

  Ryanodine Receptors (RyRs) release Ca2+ from the endoplasmic and sarcoplasmic reticulum. Mutations in RyR are linked to malignant hyperthermia (MH), myopathies, and arrhythmias. Here, a collection of cryoEM structures provides insights into the molecular consequences of MHrelated RyR mutation R615C, and how apoCaM opens RyR1.

  • Kellie A. Woll
  • , Omid Haji-Ghassemi
  •  & Filip Van Petegem

• Article
  03 April 2019 | Open Access

  Recollection in the human hippocampal-entorhinal cell circuitry

  The hippocampus is involved both in episodic memory recall and scene processing. Here, the authors show that hippocampal neurons first process scene cues before coordinating memory-guided pattern completion in adjacent entorhinal cortex.

  • Bernhard P. Staresina
  • , Thomas P. Reber
  •  & Florian Mormann

• Article
  27 February 2019 | Open Access

  Deep brain activities can be detected with magnetoencephalography

  Magnetoencephalography (MEG) is a non-invasive method of measuring neural activity but the hippocampus and amygdala are difficult to measure with MEG because of their deep localization. Here, the authors show with simultaneous MEG and invasive recordings that hippocampus and amygdala activity can be retrieved from the surface.

  • Francesca Pizzo
  • , N. Roehri
  •  & C. G. Bénar

• Article
  14 February 2019 | Open Access

  Subcortical electrophysiological activity is detectable with high-density EEG source imaging

  Electroencephalography (EEG) allows the measurement of electrical signals associated with brain activity, but it is unclear if EEG can accurately measure subcortical activity. Here, the authors show that source dynamics, reconstructed from scalp EEG, correlate with activity recorded from human thalamus and nucleus accumbens.

  • Martin Seeber
  • , Lucia-Manuela Cantonas
  •  & Christoph M. Michel

• Article
  07 February 2019 | Open Access

  Differential influences of environment and self-motion on place and grid cell firing

  Place cells and grid cells are known to encode spatial information about an animal’s location relative to the surrounding environment. Here, the authors show that place cells predominantly encode environmental sensory inputs, while grid cell activity reflects a greater influence of physical motion.

  • Guifen Chen
  • , Yi Lu
  •  & Neil Burgess

• Article
  07 August 2018 | Open Access

  ATP activates bestrophin ion channels through direct interaction

  Human Bestrophin1 (hBest1), a calcium-activated chloride channel in retinal pigment epithelium (RPE), is essential for retina physiology. Using electrophysiological and structural approaches, the authors uncover an ATP-dependent activation mechanism of hBest1, and identify an ATP-binding motif.

  • Yu Zhang
  • , Alec Kittredge
  •  & Tingting Yang

• Article
  13 November 2017 | Open Access

  Nanopore electric snapshots of an RNA tertiary folding pathway

  While RNA folding is critical for its function, study of this process is challenging. Here, the authors combine nanopore single-molecule manipulation with theoretical analysis to follow the folding of an RNA pseudoknot, monitoring the intermediate states and the kinetics of their interconversion.

  • Xinyue Zhang
  • , Dong Zhang
  •  & Li-Qun Gu