Signalling gradients

Definition

A signalling gradient is a progressive increase or decrease in the levels of a signalling molecule across a tissue or cell, usually arising as a result of the diffusion of soluble signalling molecules from their sources. Gradients of signalling molecules are involved in processes including tissue patterning, chemotaxis and axon guidance

Latest Research and Reviews

  • Research |

    Preventing netrin secretion from floor-plate cells at the midline does not disrupt axonal guidance; commissural axons develop normally and the data suggest that netrin may influence axons locally by promoting growth cone adhesion.

    • Chloé Dominici
    • , Juan Antonio Moreno-Bravo
    • , Sergi Roig Puiggros
    • , Quentin Rappeneau
    • , Nicolas Rama
    • , Pauline Vieugue
    • , Agns Bernet
    • , Patrick Mehlen
    •  & Alain Chédotal
    Nature 545, 350–354
  • Research |

    PSD-95 is one of the most abundant proteins at synapses and underlies synapse development and function. Hruska and colleagues show that the synaptic localization and turnover of PSD-95 relies on a direct interaction with the trans-synaptic organizer ephrin-B3, which is negatively regulated by neuronal activity through MAPK-dependent phosphorylation of ephrin-B3.

    • Martin Hruska
    • , Nathan T Henderson
    • , Nan L Xia
    • , Sylvain J Le Marchand
    •  & Matthew B Dalva
    Nature Neuroscience 18, 1594–1605
  • Research | | open

    Gradients of the secreted morphogen Sonic Hedgehog (Shh) pattern the neural tube in vertebrates. Cohen et al. quantify Shh signalling in developing mice, and by constructing a computational model of the process, identify mechanisms by which the dynamics of Shh signalling are regulated.

    • Michael Cohen
    • , Anna Kicheva
    • , Ana Ribeiro
    • , Robert Blassberg
    • , Karen M. Page
    • , Chris P. Barnes
    •  & James Briscoe
  • Reviews |

    Acute exposure to a variety of pathogens or inflammatory insults leads to a well-characterized set of responses in the CNS, aimed at promoting the clearance of the infecting agent. In this review, the authors examine the various symptoms of this 'sickness syndrome' and the actions of prostaglandins in linking inflammation with these CNS responses.

    • Clifford B Saper
    • , Andrej A Romanovsky
    •  & Thomas E Scammell
    Nature Neuroscience 15, 1088–1095
  • Research | | open

    Epileptic seizures generate aberrant neurogenesis in the adult mouse hippocampal region but how animals cope with abnormal neurogenesis remains unknown. Here the authors show that microglia are activated through TLR9 signaling and that this leads to sustained expression of TNF-α which attenuates induced aberrant neurogenesis.

    • Taito Matsuda
    • , Naoya Murao
    • , Yuki Katano
    • , Berry Juliandi
    • , Jun Kohyama
    • , Shizuo Akira
    • , Taro Kawai
    •  & Kinichi Nakashima

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