Research Highlight |
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Functional ultrasound localization microscopy reveals brain-wide neurovascular activity on a microscopic scale
Functional ultrasound localization microscopy monitors cerebrovascular blood flow by detecting the flow of injected microbubbles, providing access to brain activity at high spatiotemporal resolution.
- Noémi Renaudin
- , Charlie Demené
- & Mickael Tanter
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Article |
Chronically implantable LED arrays for behavioral optogenetics in primates
An implantable array of LEDs called the Opto-Array facilitates optogenetic manipulations in the nonhuman primate brain.
- Rishi Rajalingham
- , Michael Sorenson
- & Arash Afraz
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Article |
Miniaturized head-mounted microscope for whole-cortex mesoscale imaging in freely behaving mice
The mini-mScope is a miniature microscope that can image neural activity at the mesoscale in most of the dorsal cortex of freely behaving mice.
- Mathew L. Rynes
- , Daniel A. Surinach
- & Suhasa B. Kodandaramaiah
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Article |
A virtual reality system to analyze neural activity and behavior in adult zebrafish
Complex behaviors and the underlying neural activity in adult zebrafish can be accessed through a virtual reality system in combination with two-photon microscopy.
- Kuo-Hua Huang
- , Peter Rupprecht
- & Rainer W. Friedrich
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Comment |
Imaging whole nervous systems: insights into behavior from worms to fish
The development of systems combining rapid volumetric imaging with three-dimensional tracking has enabled the measurement of brain-wide dynamics in freely behaving animals such as worms, flies, and fish. These advances provide an exciting opportunity to understand the organization of neural circuits in the context of voluntary and natural behaviors. In this Comment, we highlight recent progress in this burgeoning area of research.
- John A. Calarco
- & Aravinthan D. T. Samuel
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Article |
Transparent Danionella translucida as a genetically tractable vertebrate brain model
The combination of transparency, small brain size and genetic access positions Danionella translucida as a promising model organism for functional imaging of neuronal circuits, especially during complex behaviors in adults.
- Lisanne Schulze
- , Jörg Henninger
- & Benjamin Judkewitz
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News & Views |
Tracking microscopy enables whole-brain imaging in freely moving zebrafish
Efficient tracking and optical whole-brain imaging at single-cell resolution in freely behaving zebrafish larvae pave the way for quantitative investigation of circuits underlying complex behaviors.
- Olivier Thouvenin
- & Claire Wyart
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Brief Communication |
NeuBtracker—imaging neurobehavioral dynamics in freely behaving fish
NeuBtracker is an open-source platform that enables simultaneous imaging of behavior and neural activity in freely behaving zebrafish larvae. Its performance is demonstrated during several spontaneous or stimulus-induced behaviors.
- Panagiotis Symvoulidis
- , Antonella Lauri
- & Gil G Westmeyer
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Article |
Pan-neuronal calcium imaging with cellular resolution in freely swimming zebrafish
A tracking microscope for imaging neuronal activity at single-cell resolution in freely swimming zebrafish larvae is described. This technology allows functional imaging during behaviors that have previously been inaccessible to real-time analysis.
- Dal Hyung Kim
- , Jungsoo Kim
- & Drew N Robson
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Article |
Virtual reality for freely moving animals
FreemoVR is a virtual reality system for freely moving animals. The versatile platform is demonstrated in various experiments with Drosophila, zebrafish, and mice.
- John R Stowers
- , Maximilian Hofbauer
- & Andrew D Straw
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Brief Communication |
Random-access scanning microscopy for 3D imaging in awake behaving animals
Random-access line scanning enables neural activity to be monitored at high speed in neurons and dendrites that are sparsely distributed in three dimensions. The approach is demonstrated in behaving mice.
- K M Naga Srinivas Nadella
- , Hana Roš
- & R Angus Silver
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Article |
Mapping brain activity at scale with cluster computing
An open-source library of analytical tools for mapping large-scale patterns of brain activity using cluster computing finds structure in two-photon imaging data from mouse and whole-brain light-sheet functional imaging data from behaving larval zebrafish. Vladimirov et al., also in this issue, describes the light-sheet functional imaging system used here.
- Jeremy Freeman
- , Nikita Vladimirov
- & Misha B Ahrens
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Brief Communication |
Deciphering laminar-specific neural inputs with line-scanning fMRI
A line-scanning method is applied to obtain onset times of fMRI responses in rats. The authors show that onset time of the fMRI response can be used to infer information about which cortical layers receive the connectivity input from other brain areas.
- Xin Yu
- , Chunqi Qian
- & Alan P Koretsky
Predicting neural activity from facial expressions