Latest Research and Reviews

News and Comment

  • Comments and Opinion |

    Developing catalytic reactions for organic synthesis is the central goal of countless research groups worldwide. High-throughput experimentation is invaluable for this pursuit, with the requisite tools becoming increasingly available to both industrial and academic research labs.

    • C. Liana Allen
    • , David C. Leitch
    • , Michael S. Anson
    •  & Matthew A. Zajac
  • News and Views |

    Current drug discovery efforts focus on proteins because of their ability to form stable, structured pockets. A recent study demonstrates that targeting stable, structured bioactive RNA motifs, such as autocatalytic introns, may provide a novel method of expanding druggability and selectivity.

    • James Palacino
    Nature Chemical Biology 14, 1068-1069
  • Editorial |

    Encoded chemical libraries can be used to screen a vast array of compounds against a protein target to identify potent binders. A collection of articles in this issue discuss different methods to increase the chemical space sampled by encoded macrocycle libraries and the advantages that such libraries offer for discovering new drug leads.

  • Comments and Opinion |

    Ghotas Evindar, Chemistry Group Leader at GlaxoSmithKline, talks with Nature Chemistry about the advantages of using encoded libraries in drug discovery and the challenges these technologies present.

    • Russell Johnson
    Nature Chemistry 10, 690-691
  • News and Views |

    Certain drug targets have been deemed undruggable because of the difficulty in finding pharmacologically useful inhibitors. Now, two teams have developed exciting technologies for the creation of diverse collections of macrocyclic molecules and have demonstrated their usefulness for discovering macrocyclic inhibitors.

    • Emil S. Iqbal
    •  & Matthew C. T. Hartman
    Nature Chemistry 10, 692-694