Schizosaccharomyces pombe

Schizosaccharomyces pombe, or fission yeast, is a unicellular fungus and a model organism used to study subjects including cell cycle control, DNA replication and genome integrity.

Latest Research and Reviews

  • Research | | open

    An essential gene may become non-essential when another gene is mutated. Here, the authors investigate this type of digenic interaction, termed ‘bypass of essentiality’, in the fission yeast Schizosaccharomyces pombe, and show that bypassable essential genes are common and share certain features.

    • Jun Li
    • , Hai-Tao Wang
    • , Wei-Tao Wang
    • , Xiao-Ran Zhang
    • , Fang Suo
    • , Jing-Yi Ren
    • , Ying Bi
    • , Ying-Xi Xue
    • , Wen Hu
    • , Meng-Qiu Dong
    •  & Li-Lin Du
  • Research | | open

    Cell shape is determined by a combination of biochemical regulation and mechanical forces. By imaging the dynamic behaviour of growth regulatory proteins in fission yeast and integrating these data within a mechanical model, Abenza et al. find that exocytosis plays a dominant role in shaping growth domains.

    • Juan F. Abenza
    • , Etienne Couturier
    • , James Dodgson
    • , Johanna Dickmann
    • , Anatole Chessel
    • , Jacques Dumais
    •  & Rafael E. Carazo Salas
  • Research | | open

    The evolutionarily conserved MTREC complex promotes degradation of meiotic mRNAs and regulatory ncRNAs. Here the authors show that MTREC also targets cryptic unstable transcripts and unspliced pre-mRNAs for degradation by the nuclear exosome, while the TRAMP complex has only a minor role in this process.

    • Yang Zhou
    • , Jianguo Zhu
    • , Géza Schermann
    • , Corina Ohle
    • , Katja Bendrin
    • , Rie Sugioka-Sugiyama
    • , Tomoyasu Sugiyama
    •  & Tamás Fischer
  • Research |

    Genome-wide single-gene deletion libraries can be important tools for understanding the molecular workings of an organism, but have only been created for a single eukaryotic species, Saccharomyces cerevisiae. Now, Kim et al. present a second collection of deletion mutants that covers 98.4% of the genes of Schizosaccharomyces pombe, allowing a systematic comparison of gene essentiality and knockout phenotypes between two eukaryotic species.

    • Dong-Uk Kim
    • , Jacqueline Hayles
    • , Dongsup Kim
    • , Valerie Wood
    • , Han-Oh Park
    • , Misun Won
    • , Hyang-Sook Yoo
    • , Trevor Duhig
    • , Miyoung Nam
    • , Georgia Palmer
    • , Sangjo Han
    • , Linda Jeffery
    • , Seung-Tae Baek
    • , Hyemi Lee
    • , Young Sam Shim
    • , Minho Lee
    • , Lila Kim
    • , Kyung-Sun Heo
    • , Eun Joo Noh
    • , Ah-Reum Lee
    • , Young-Joo Jang
    • , Kyung-Sook Chung
    • , Shin-Jung Choi
    • , Jo-Young Park
    • , Youngwoo Park
    • , Hwan Mook Kim
    • , Song-Kyu Park
    • , Hae-Joon Park
    • , Eun-Jung Kang
    • , Hyong Bai Kim
    • , Hyun-Sam Kang
    • , Hee-Moon Park
    • , Kyunghoon Kim
    • , Kiwon Song
    • , Kyung Bin Song
    • , Paul Nurse
    •  & Kwang-Lae Hoe
    Nature Biotechnology 28, 617-623

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