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Reward is an appealing or appetitive concept that can be applied to an object or a situation, which positively reinforces a response, satisfies a motive or intent, or signals pleasure.
The authors report data from the emergency department AURORA study to characterize resilience in more detail than the absence of psychopathology after trauma.
The dorsal hippocampus plays an important role for spatial memory, but how its outputs guide behavior is not fully understood. Here, the authors show that nucleus accumbens-specific hippocampal projection neurons carry a highly conjunctive code of spatial and action information that directs spatial reward memory-guided appetitive behaviors.
Humans often interact without knowing the cooperative or competitive intentions of others. Here, the authors determined the neurocomputational mechanisms engaged in adapting to fluctuating intentions of others over repeated social interactions.
Muller et al. demonstrate that reward signals recorded from the frontal cortex of nonhuman primates exhibit a population-based scheme for learning probability distributions over reward values. This study provides evidence that neural signals outside of the midbrain reflect the principles of distributional reinforcement-learning theory.
A study in mice helps to resolve a debate surrounding striatal DA dynamics and reward benefit or cost and also reveals motivation and transient striatal DA release have a bidirectional causal relationship.
Increasing levels of glial-derived neurotrophic factor using a gene-therapy approach in a macaque model of alcohol use disorder resulted in a lower tendency to relapse into alcohol consumption after a period of abstinence.
