Recombinant protein therapy articles within Nature

Featured

• Article
  28 June 2023 | Open Access

  GDF15 promotes weight loss by enhancing energy expenditure in muscle

  GDF15 treatment in mice counteracts compensatory reductions in energy expenditure, resulting in greater weight loss and reductions in non-alcoholic fatty liver disease compared to caloric restriction alone.

  • Dongdong Wang
  • , Logan K. Townsend
  •  & Gregory R. Steinberg

• Article | 24 June 2020

  IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy

  An engineered version of IL-18 that is resistant to binding by the soluble decoy receptor IL-18BP shows strong anti-tumour activity in mouse models of cancer.

  • Ting Zhou
  • , William Damsky
  •  & Aaron M. Ring