Polycystic ovary syndrome

Definition

Polycystic ovary syndrome is a complex endocrine disorder of unknown aetiology that is characterized by anovulation, excessive amounts or effects of androgens and insulin resistance. The exact classification and definition is, however, highly debated.

Latest Research and Reviews

  • Reviews |

    Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Here, Azziz et al. describe the current state of knowledge regarding the epidemiology, pathophysiology, diagnosis, management and future investigational directions of the disorder.

    • Ricardo Azziz
    • , Enrico Carmina
    • , ZiJiang Chen
    • , Andrea Dunaif
    • , Joop S. E. Laven
    • , Richard S. Legro
    • , Daria Lizneva
    • , Barbara Natterson-Horowtiz
    • , Helena J. Teede
    •  & Bulent O. Yildiz
  • Research | | open

    Anti-Müllerian hormone (AMH) plays a role in sexual differentiation and gonadal function, but extra-gonadal effects of AMH are not known. Here Cimino et al. show that AMH activates a subset of gonadotrophin-releasing hormone (GnRH)-releasing neurons, contributing to luteinizing hormone secretion from the pituitary gland.

    • Irene Cimino
    • , Filippo Casoni
    • , Xinhuai Liu
    • , Andrea Messina
    • , Jyoti Parkash
    • , Soazik P. Jamin
    • , Sophie Catteau-Jonard
    • , Francis Collier
    • , Marc Baroncini
    • , Didier Dewailly
    • , Pascal Pigny
    • , Mel Prescott
    • , Rebecca Campbell
    • , Allan E. Herbison
    • , Vincent Prevot
    •  & Paolo Giacobini
  • Research | | open

    This paper describes the largest genome-wide association study to date on polycystic ovary syndrome (PCOS), a common reproductive disorder in women. Six genetic loci—including known targets of cancer chemotherapy—were identified, and the authors infer causal and balancing selection mechanisms involved in PCOS risk and susceptibility.

    • Felix R. Day
    • , David A. Hinds
    • , Joyce Y. Tung
    • , Lisette Stolk
    • , Unnur Styrkarsdottir
    • , Richa Saxena
    • , Andrew Bjonnes
    • , Linda Broer
    • , David B. Dunger
    • , Bjarni V. Halldorsson
    • , Debbie A. Lawlor
    • , Guillaume Laval
    • , Iain Mathieson
    • , Wendy L. McCardle
    • , Yvonne Louwers
    • , Cindy Meun
    • , Susan Ring
    • , Robert A. Scott
    • , Patrick Sulem
    • , André G. Uitterlinden
    • , Nicholas J. Wareham
    • , Unnur Thorsteinsdottir
    • , Corrine Welt
    • , Kari Stefansson
    • , Joop S. E. Laven
    • , Ken K. Ong
    •  & John R. B. Perry
  • Research | | open

    Polycystic Ovary Sydrome is a highly heritable, complex reproductive disorder with unknown underlying genetic factors. Here Hayes and Urbanek et al. identify three loci in European women strongly associated with neuroendocrine changes and disease susceptibility.

    • M. Geoffrey Hayes
    • , Margrit Urbanek
    • , David A. Ehrmann
    • , Loren L. Armstrong
    • , Ji Young Lee
    • , Ryan Sisk
    • , Tugce Karaderi
    • , Thomas M. Barber
    • , Mark I. McCarthy
    • , Stephen Franks
    • , Cecilia M. Lindgren
    • , Corrine K. Welt
    • , Evanthia Diamanti-Kandarakis
    • , Dimitrios Panidis
    • , Mark O. Goodarzi
    • , Ricardo Azziz
    • , Yi Zhang
    • , Roland G. James
    • , Michael Olivier
    • , Ahmed H. Kissebah
    • , Reproductive Medicine Network
    • , Ruben Alvero
    • , Huiman X. Barnhart
    • , Valerie Baker
    • , Kurt T. Barnhart
    • , G. Wright Bates
    • , Robert G. Brzyski
    • , Bruce R. Carr
    • , Sandra A. Carson
    • , Peter Casson
    • , Nicholas A. Cataldo
    • , Gregory Christman
    • , Christos Coutifaris
    • , Michael P. Diamond
    • , Esther Eisenberg
    • , Gabriella G. Gosman
    • , Linda C. Giudice
    • , Daniel J. Haisenleder
    • , Hao Huang
    • , Stephen A. Krawetz
    • , Scott Lucidi
    • , Peter G. McGovern
    • , Evan R. Myers
    • , John E. Nestler
    • , Dana Ohl
    • , Nanette Santoro
    • , William D. Schlaff
    • , Peter Snyder
    • , Michael P. Steinkampf
    • , J. C. Trussell
    • , Rebecca Usadi
    • , Qingshang Yan
    • , Heping Zhang
    • , Elisabet Stener-Victorin
    • , Richard S. Legro
    •  & Andrea Dunaif
  • Research |

    Zi-Jiang Chen and colleagues report a genome-wide association analysis for polycystic ovary syndrome (PCOS) in Han Chinese. They identify eight new susceptibility loci for PCOS in this population.

    • Yongyong Shi
    • , Han Zhao
    • , Yuhua Shi
    • , Yunxia Cao
    • , Dongzi Yang
    • , Zhiqiang Li
    • , Bo Zhang
    • , Xiaoyan Liang
    • , Tao Li
    • , Jianhua Chen
    • , Jiawei Shen
    • , Junzhao Zhao
    • , Li You
    • , Xuan Gao
    • , Dongyi Zhu
    • , Xiaoming Zhao
    • , Ying Yan
    • , Yingying Qin
    • , Wenjin Li
    • , Junhao Yan
    • , Qingzhong Wang
    • , Junli Zhao
    • , Ling Geng
    • , Jinlong Ma
    • , Yueran Zhao
    • , Guang He
    • , Aiping Zhang
    • , Shuhua Zou
    • , Aijun Yang
    • , Jiayin Liu
    • , Weidong Li
    • , Baojie Li
    • , Chunling Wan
    • , Ying Qin
    • , Juanzi Shi
    • , Jing Yang
    • , Hong Jiang
    • , Jin-e Xu
    • , Xiujuan Qi
    • , Yun Sun
    • , Yajie Zhang
    • , Cuifang Hao
    • , Xiuqing Ju
    • , Dongni Zhao
    • , Chun-e Ren
    • , Xiuqing Li
    • , Wei Zhang
    • , Yiwen Zhang
    • , Jiangtao Zhang
    • , Di Wu
    • , Changming Zhang
    • , Lin He
    •  & Zi-Jiang Chen
    Nature Genetics 44, 1020–1025

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