Phosphoproteins articles within Nature Communications

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  • Article
    | Open Access

    Direct modulation of protein by artificial catalysts as enzyme mimetics remains hindered by the lack of highly efficient catalytic centers. Here, the authors present the development of artificial protein modulators (APROMs) with protein phosphatase-like characteristics, catalytically reprogram the biological function of α-synuclein.

    • Peihua Lin
    • , Bo Zhang
    •  & Daishun Ling

  • Article
    | Open Access

    Fat and Dachsous are large cadherins that regulate planar polarity as a receptor:ligand pair. Here, authors determine the structure of the Fat:Dachsous complex to uncover the molecular determinants of binding and posttranslational modification.

    • Elliot Medina
    • , Yathreb Easa
    •  & Vincent C. Luca

  • Article
    | Open Access

    Here, Giansanti et al. perform a system-wide and time-resolved characterization of the changes in the host cell proteome and phosphoproteome of cells infected with the enterovirus coxsackievirus B3 during a full round of replication and identify mTORC1 signalling as a major regulation network during virus infection.

    • Piero Giansanti
    • , Jeroen R. P. M. Strating
    •  & Frank J. M. van Kuppeveld

  • Article
    | Open Access

    Protein phosphatases play an essential role in signal transduction, but are understudied due to the difficulties in detecting phosphate removal and the lack of good inhibitors. Here the authors develop a light-activated protein phosphatase using photocaged, unnatural amino acids and use it to study ERK nuclear translocation.

    • Taylor M. Courtney
    •  & Alexander Deiters

  • Article
    | Open Access

    Thrombospondin-1 (THSB1) is a component of the ECM with a role in regulating cancer development and tumour vasculature. Here, the authors show that TGF-beta-induced THBS1 expression contributes to the invasive behaviour of GBM cells and promotes resistance to antiangiogenic therapy partially through interaction with CD47.

    • Thomas Daubon
    • , Céline Léon
    •  & Andréas Bikfalvi

  • Article
    | Open Access

    It has previously been established that DNA end resection in yeast and in humans is under CDK control. Here the authors explain how phosphorylation regulates the capacity of Sae2 — the yeast orthologue of human CtIP — to promote DNA end resection.

    • Elda Cannavo
    • , Dominic Johnson
    •  & Petr Cejka

  • Article
    | Open Access

    The Hsp90 chaperone cycle is influenced by multiple phosphorylation events but their regulatory functions are poorly understood. Here, the authors show that phosphorylation and unfolding of cochaperone Cdc37 tailors the Hsp90 chaperone cycle by recruiting kinases that promote distinct phosphorylation patterns.

    • Ashleigh B. Bachman
    • , Dimitra Keramisanou
    •  & Ioannis Gelis

  • Article
    | Open Access

    RAD54 stimulates activity of the RAD51 recombinase and catalyzes branch migration of Holliday junctions during DNA repair and recombination. Here the authors show that the N-terminal domain of RAD54 mediates RAD54 oligomerization to promote branch migration, and is the target of phosphorylation that inhibits oligomerization and branch migration but not RAD51 stimulation.

    • Nadish Goyal
    • , Matthew J. Rossi
    •  & Alexander V. Mazin

  • Article
    | Open Access

    The C-terminal domain (CTD) of RNA polymerase II is composed of a series of heptad repeats that exhibit some degree of sequence variation and that are subject to extensive phosphorylation. Here the authors provide evidence that local structural variations within the CTD are functionally important.

    • Bede Portz
    • , Feiyue Lu
    •  & David S. Gilmour

  • Article
    | Open Access

    Plant cryptochromes are regulated by blue-light dependent phosphorylation. Here the authors map thein vivo phosphorylation sites of Arabidopsiscryptochrome 2 and identify four closely related kinases that act to both activate and destabilize the receptor in response to blue light.

    • Qing Liu
    • , Qin Wang
    •  & Chentao Lin

  • Article
    | Open Access

    Gephyrin is a cytoplasmic scaffolding protein that selectively forms postsynaptic scaffolds at GABAergic and glycinergic synapses. Here the authors characterize regulatory mechanisms determining gephyrin scaffolding and GABAA receptor synaptic transmission that involve acetylation, SUMOylation and phosphorylation.

    • Himanish Ghosh
    • , Luca Auguadri
    •  & Shiva K. Tyagarajan

  • Article
    | Open Access

    The inability to produce recombinant phosphoproteins has hindered research into their structure and function. Here the authors develop a cell-free protein synthesis platform to site-specifically incorporate phosphoserine into proteins at high yields, and recapitulate a MEK1 kinase signalling cascade.

    • Javin P. Oza
    • , Hans R. Aerni
    •  & Michael C. Jewett

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