Paediatric cancer

Paediatric cancers are malignancies that occur in young children.The most common childhood cancers are leukaemia and brain tumors, such as gliomas.

Latest Research and Reviews

  • Reviews |

    This Primer by Pfister and colleagues reviews the molecular genetics, diagnosis and management of medulloblastoma and touches upon the quality of life of patients and future outlooks.

    • Paul A. Northcott
    • , Giles W. Robinson
    • , Christian P. Kratz
    • , Donald J. Mabbott
    • , Scott L. Pomeroy
    • , Steven C. Clifford
    • , Stefan Rutkowski
    • , David W. Ellison
    • , David Malkin
    • , Michael D. Taylor
    • , Amar Gajjar
    •  & Stefan M. Pfister
  • Research | | open

    • Klaartje Somers
    • , Victoria W. Wen
    • , Shiloh M. C. Middlemiss
    • , Brenna Osborne
    • , Helen Forgham
    • , MoonSun Jung
    • , Mawar Karsa
    • , Molly Clifton
    • , Angelika Bongers
    • , Jixuan Gao
    • , Chelsea Mayoh
    • , Newsha Raoufi-Rad
    • , Eric P. Kusnadi
    • , Kate M. Hannan
    • , David A. Scott
    • , Alan Kwek
    • , Bing Liu
    • , Claudia Flemming
    • , Daria A. Chudakova
    • , Ruby Pandher
    • , Tim W. Failes
    • , James Lim
    • , Andrea Angeli
    • , Andrei L. Osterman
    • , Toshihiko Imamura
    • , Ursula R. Kees
    • , Claudiu T. Supuran
    • , Richard B. Pearson
    • , Ross D. Hannan
    • , Thomas P. Davis
    • , Joshua McCarroll
    • , Maria Kavallaris
    • , Nigel Turner
    • , Andrei V. Gudkov
    • , Michelle Haber
    • , Murray D. Norris
    •  & Michelle J. Henderson
    Oncogene, 1-19
  • Research | | open

    Medulloblastoma is one of the most prevalent malignant brain tumors in children and has very poor prognosis. In this study, the authors show, using a mouse model of medulloblastoma, that Gfi1 promotes tumor growth by recruiting Lsd1, that this interaction inhibits genes involved in neuronal differentiation, and that Lsd1 may be a therapeutic target in Gfi1-activated tumors.

    • Catherine Lee
    • , Vasilisa A. Rudneva
    • , Serap Erkek
    • , Marc Zapatka
    • , Lianne Q. Chau
    • , Silvia K. Tacheva-Grigorova
    • , Alexandra Garancher
    • , Jessica M. Rusert
    • , Ozlem Aksoy
    • , Robin Lea
    • , Helai P. Mohammad
    • , Jianxun Wang
    • , William A. Weiss
    • , H. Leighton Grimes
    • , Stefan M. Pfister
    • , Paul A. Northcott
    •  & Robert J. Wechsler-Reya

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