Oligodendrocyte

Oligodendrocytes are a type of large glial cell found in the central nervous system. Oligodendrocytes produce the myelin sheath insulating neuronal axons (analogous to Schwann cells in the peripheral nervous system), although some oligodendrocytes (called satellite oligodendrocytes) are not involved in myelination.

Latest Research and Reviews

  • Research |

    Single-nucleus RNA sequencing analysis identifies different subclusters of oligodendroglia in white matter from individuals with multiple sclerosis compared with controls, and these differences may be important for understanding disease progression.

    • Sarah Jäkel
    • , Eneritz Agirre
    • , Ana Mendanha Falcão
    • , David van Bruggen
    • , Ka Wai Lee
    • , Irene Knuesel
    • , Dheeraj Malhotra
    • , Charles ffrench-Constant
    • , Anna Williams
    •  & Gonçalo Castelo-Branco
    Nature, 1-5
  • Research |

    There are no new oligodendrocytes in potentially remyelinated multiple sclerosis shadow plaques, although oligodendrocyte generation is increased in the normal appearing white matter of patients with aggressive disease, informing the development of new therapies.

    • Maggie S. Y. Yeung
    • , Mehdi Djelloul
    • , Embla Steiner
    • , Samuel Bernard
    • , Mehran Salehpour
    • , Göran Possnert
    • , Lou Brundin
    •  & Jonas Frisén
    Nature, 1-5
  • Research |

    Single-cell RNA-seq of a mouse model of multiple sclerosis uncovers new oligodendrocyte populations and putative disease markers and suggests new mechanisms underlying the pathogenesis of the disease.

    • Ana Mendanha Falcão
    • , David van Bruggen
    • , Sueli Marques
    • , Mandy Meijer
    • , Sarah Jäkel
    • , Eneritz Agirre
    • , Samudyata
    • , Elisa M. Floriddia
    • , Darya P. Vanichkina
    • , Charles ffrench-Constant
    • , Anna Williams
    • , André Ortlieb Guerreiro-Cacais
    •  & Gonçalo Castelo-Branco
    Nature Medicine 24, 1837-1844
  • Research | | open

    The isolation and propagation of oligodendroglial cells from postnatal animals can be impractical for functional genetic studies. This study highlights the potential of a new approach to rapidly generate oligodendrocytes and their progenitors from mouse embryonic and induced pluripotent stem cells, independent of mouse strain or mutational status.

    • Angela M. Lager
    • , Olivia G. Corradin
    • , Jared M. Cregg
    • , Matthew S. Elitt
    • , H. Elizabeth Shick
    • , Benjamin L. L. Clayton
    • , Kevin C. Allan
    • , Hannah E. Olsen
    • , Mayur Madhavan
    •  & Paul J. Tesar
  • Research | | open

    Oligodendrocyte progenitor cells (OPCs) undergo asymmetric cell division, and disruption of such mechanism can generate oligodendroglioma precursors. Here, Daynac and colleagues show that Lgl1 regulates asymmetric division and differentiation of OPCs by interfering with the endocytosis pathway, and that Lgl1 knockout can lead to gliomagenesis.

    • Mathieu Daynac
    • , Malek Chouchane
    • , Hannah Y. Collins
    • , Nicole E. Murphy
    • , Noemi Andor
    • , Jianqin Niu
    • , Stephen P. J. Fancy
    • , William B. Stallcup
    •  & Claudia K. Petritsch

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