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Article
| Open Access
Simultaneous single-cell three-dimensional genome and gene expression profiling uncovers dynamic enhancer connectivity underlying olfactory receptor choice
LiMCA offers a tool for co-profiling 3D genome structure and gene expression at the single-cell level, enabling researchers to elucidate the olfactory receptor gene selection process.
- Honggui Wu
- , Jiankun Zhang
- & X. Sunney Xie
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Article |
BAcTrace, a tool for retrograde tracing of neuronal circuits in Drosophila
BAcTrace is a predominantly retrograde tracing tool for connectomic analyses in Drosophila.
- Sebastian Cachero
- , Marina Gkantia
- & Gregory S. X. E. Jefferis
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Brief Communication |
Flyception: imaging brain activity in freely walking fruit flies
Flyception is a tracking and imaging system that enables the monitoring of brain activity in freely walking fruit flies, making the analysis of calcium dynamics possible in studies of neural mechanisms such as those that underlie social behaviors.
- Dhruv Grover
- , Takeo Katsuki
- & Ralph J Greenspan
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Brief Communication |
Dexterous robotic manipulation of alert adult Drosophila for high-content experimentation
A robotic system is described that uses machine vision guidance to pick, manipulate, inspect and dissect individual flies, enabling large-scale and automated approaches to the analysis of morphology, behavior and neural dynamics.
- Joan Savall
- , Eric Tatt Wei Ho
- & Mark J Schnitzer
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Article |
Controlling airborne cues to study small animal navigation
A device for generating precise spatial and temporal patterns of airborne odorants is reported. In combination with machine vision tracking software, the authors use the device to monitor navigation of freely moving Drosophila melanogaster larvae.
- Marc Gershow
- , Matthew Berck
- & Aravinthan D T Samuel
LiMCA: Hi-C gets an RNA twist