Obsessive compulsive disorder articles within Nature Communications

Featured

• Article
  04 September 2023 | Open Access

  Unraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model

  The mechanisms of deep-brain stimulation for psychiatric disorders remain insufficiently understood. Here, the authors identified recruitment of cortico-striatal regions, in particular the medial orbitofrontal cortex, as a mechanism to treat compulsivity.

  • Bastijn J. G. van den Boom
  • , Alfredo Elhazaz-Fernandez
  •  & Ingo Willuhn

• Article
  27 June 2023 | Open Access

  Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls

  The neurochemical basis of compulsive behaviour is not well understood. Here, the authors show that levels of glutamate and GABA in the supplementary motor area and anterior cingulate cortex relate to compulsive behaviour in healthy controls and individuals with OCD.

  • Marjan Biria
  • , Paula Banca
  •  & Trevor W. Robbins

• Article
  15 October 2021 | Open Access

  Ketamine increases activity of a fronto-striatal projection that regulates compulsive behavior in SAPAP3 knockout mice

  Intravenous infusion of ketamine rapidly reduces obsessive-compulsive disorder symptoms. Here, the authors show in mice that ketamine acts by increasing activity in a fronto-striatal circuit that causally controls compulsive grooming behaviour.

  • Gwynne L. Davis
  • , Adelaide R. Minerva
  •  & Lisa A. Gunaydin

• Article
  03 July 2020 | Open Access

  A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder

  Li et al. analyzed structural connectivity of deep brain stimulation electrodes in 50 patients suffering from obsessive-compulsive disorder operated at four centers. Connectivity to a specific tract within the anterior limb of the internal capsule was associated with optimal treatment response across cohorts, surgeons and centers.

  • Ningfei Li
  • , Juan Carlos Baldermann
  •  & Andreas Horn

• Article
  04 April 2019 | Open Access

  Deep brain stimulation of the internal capsule enhances human cognitive control and prefrontal cortex function

  Deep brain stimulation (DBS) is a promising treatment for psychiatric disorders, but its mechanism in relieving symptoms is unclear. Here, the authors show that DBS of ventral internal capsule/ventral striatum (VCVS) may act by enhancing prefrontal cortex oscillations that in turn enhance cognitive control.

  • A. S. Widge
  • , S. Zorowitz
  •  & D. D. Dougherty

• Article
  17 October 2017 | Open Access

  Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder

  Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with symptoms including intrusive thoughts and time-consuming repetitive behaviors. Here Noh and colleagues identify genes enriched for functional variants associated with increased risk of OCD.

  • Hyun Ji Noh
  • , Ruqi Tang
  •  & Kerstin Lindblad-Toh