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Neurological models are experimental systems that recreate aspects of human neurological development, function or disease. For example, induced pluripotent stem cells derived from patients with neurological disease, and genetic and transgenic animal models allow the study of neuronal activity and dysfunction.
Projection imaging for multi-cellular samples can be hindered by several factors, including low contrast. Here, the authors propose projective light-sheet imaging with parameter selection (props) of imaging depth, position and viewing angle.
Development of platform to integrate multiple Tissue-in-a-CUBEs in a chip for tissue-tissue interaction, demonstrated by simulating the testing of the permeability and effect of a cancer drug in a BBB-Brain cancer model.
Protocol for the fabrication of a microfluidic device and its implementation in three-dimensional human neural cultures, allowing the study of neuron–glia interactions in neuroinflammation and neurodegeneration.
Bioprinting has potential in the biofabrication of three dimensional tissues, but is poorly suited to the manipulation of neural organoids. Here, the authors develop a bioprinting platform to allow the arrangement of organoids to form assembloids.
This protocol enables the generation of human forebrain organoids from induced pluripotent stem cells with the intrinsic ability to assemble functionally integrated bilateral optic vesicles.
Two studies demonstrate the power of combining induced pluripotent stem cell technology with CRISPR-mediated gene editing to investigate neurobiological mechanisms.
Certain cellular functions in artificially reperfused pig brains can be restored and maintained several hours after initial loss of cerebral blood flow.
