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Magneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo
Magneto-gas vesicles, protein nanostructures with enhanced ultrasound signal and sensitivity, enable the non-invasive, long-term and quantitative monitoring of the mechanics of three-dimensional tissues and animals.
- Whee-Soo Kim
- , Sungjin Min
- & Jinwoo Cheon
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News & Views |
Wireless neuromodulation with porous silicon
Wireless optoelectronic devices are fabricated by controlling the porosity of p-type silicon, enabling in vivo efficient, non-genetic optoelectronic modulation of peripheral nerve activity.
- Silvestro Micera
- & Eugenio Redolfi Riva
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News & Views |
Nanocages for virus inhibition
Elaborately designed DNA icosahedral shells cage intact virions to effectively protect host cells from viral infections.
- Neha Chauhan
- & Xing Wang
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Article |
Furin-mediated intracellular self-assembly of olsalazine nanoparticles for enhanced magnetic resonance imaging and tumour therapy
An anticancer agent, olsalazine, conjugated to a cell-penetrating peptide has been synthesized and shows the ability to self-assemble intracellularly by the tumour-associated enzyme furin, with the potential for tumour therapy and chemical exchange saturation transfer magnetic resonance imaging in vivo.
- Yue Yuan
- , Jia Zhang
- & Jeff W. M. Bulte
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News & Views |
Growing gold nanoprisms with light
An adsorbed polymer directs the photochemical growth of colloidal Au single-crystal nanoprisms following visible metal excitation.
- Louis Brus
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Designer amphiphilic proteins as building blocks for the intracellular formation of organelle-like compartments
Amphiphilic proteins act as building blocks for the de novo formation of membrane-based organelles within Escherichia coli. The organelles can be selectively functionalized in vivo with unnatural amino acids and hence may permit chemical reactions inside the cell that have not been possible so far.
- Matthias C. Huber
- , Andreas Schreiber
- & Stefan M. Schiller
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Gradated assembly of multiple proteins into supramolecular nanomaterials
Peptide-based nanofibres with bioactive proteins attached can now be made such that the protein ligands are introduced in a controlled manner. This tailoring of the nanofibre’s composition enables the ratio of multiple different proteins to be highly tuned within the assemblies. By changing the protein content of the nanofibres, it is possible to adjust the antibody responses in mice to the different nanofibres.
- Gregory A. Hudalla
- , Tao Sun
- & Joel H. Collier
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News & Views |
Noodle gels for cells
Heating and cooling of peptide amphiphile suspensions converts disorganized nanofibres into liquid-crystalline nanofibre bundles that gel on addition of salts. The noodle-shaped strings of gel can entrap and align cells.
- Timothy J. Deming
An intelligent DNA nanodevice for precision thrombolysis