Monosaccharides articles within Nature Chemistry

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  • Article |

    Synthetic receptors can be used to help understand biological systems, but rarely compete in terms of affinity or selectivity. Now, a glucose-binding compound has been prepared that, despite its symmetry and simplicity, can match all but the strongest glucose-binding proteins. The high binding affinity and outstanding selectivity of this receptor may translate into biomedical applications.

    • Robert A. Tromans
    • , Tom S. Carter
    •  & Anthony P. Davis

  • Article |

    O-linked N-acetyl-glucosamine (O-GlcNAc) has been identified as an endogenous modification of α-synuclein; however, its effect on the properties of the protein is unclear. Now, recombinant protein and synthetic peptides have been combined to produce both unmodified and site-specifically O-GlcNAc-modified α-synuclein. The O-GlcNAc modification at threonine 72 was shown to inhibit the aggregation and associated toxicity of α-synuclein.

    • Nicholas P. Marotta
    • , Yu Hsuan Lin
    •  & Matthew R. Pratt

  • Article |

    Designing synthetic molecular receptors that can differentiate between specific monosaccharide guests is very challenging. Now, a helically folded oligoamide that selectively encapsulates fructose has been designed using an iterative approach that exploits the modular structure of folded synthetic oligomer sequences, in conjunction with molecular modelling and structural characterization.

    • Nagula Chandramouli
    • , Yann Ferrand
    •  & Ivan Huc

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