Peptide-like foldamers are known to be controlled by amide backbone hydrogen bonding, however, the influence of functional groups forming individual hydrogen-bond networks remains underexplored. Here, the authors report peptide-like α-γ heterofoldamers consisting of alternating α,β,γ-triamino acids, forming ordered secondary structures and folding in both organic and aqueous environments.
- David Just
- Vladimír Palivec
- Ullrich Jahn