Methylation articles within Nature Methods

Featured

• Brief Communication | 28 March 2019

  Single-cell chromatin immunocleavage sequencing (scChIC-seq) to profile histone modification

  Covalent linking of a histone-modification-specific antibody to MNase allows for the isolation of fragments with the desired histone mark, which can be amplified and sequenced. This approach is sensitive enough to profile histone modifications in single cells.

  • Wai Lim Ku
  • , Kosuke Nakamura
  •  & Keji Zhao

• Research Highlights | 27 June 2013

  Matching marks with mechanisms

  Reagents that recognize specific chemical modifications while ignoring the surrounding protein offer valuable proteomic insights.

  • Michael Eisenstein

• Brief Communication | 03 March 2013

  A Y2H-seq approach defines the human protein methyltransferase interactome

  A high-sensitivity, high-quality yeast two-hybrid screen using short-read sequencing as its readout is used to map the interactome of human methyltransferases.

  • Mareike Weimann
  • , Arndt Grossmann
  •  & Ulrich Stelzl