Metalloproteins articles within Nature Communications

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  • Article
    | Open Access

    High levels of homocysteine in cells are linked to pathological states. Here, the authors report that homocysteine inactivates catalase by modifying the heme group, impairing cellular redox homeostasis, and show that this modification occurs in cancer cells and in a cellular model of Parkinson’s disease.

    • Dominique Padovani
    • , Assia Hessani
    •  & Isabelle Artaud

  • Article
    | Open Access

    Lytic polysaccharide monooxygenases are proteins involved in the degradation of plant biomass and are promising biotechnological tools for biofuel production. Here, the authors show that their catalytic activity is significantly boosted when they are combined with photopigments and exposed to light.

    • D. Cannella
    • , K. B. Möllers
    •  & C. Felby

  • Article
    | Open Access

    The [Mo:7Fe:9S:C] iron-molybdenum cofactor (FeMoco) of nitrogenase is a large metal cluster with an important role in biological nitrogen fixation. Here, the authors use spatially resolved refinement of the anomalous scattering contributions of the iron atoms to determine the resting-state electron distribution of FeMoco.

    • Thomas Spatzal
    • , Julia Schlesier
    •  & Oliver Einsle

  • Article
    | Open Access

    Artificial metalloenzymes (ArMs) have the potential to improve transition metal reactivity in complex media. Here, the authors link a dirhodium catalyst to a prolyl oligopeptidase to create an ArM that catalyzes enantioselective olefin cyclopropanation in aqueous solution.

    • Poonam Srivastava
    • , Hao Yang
    •  & Jared C. Lewis

  • Article
    | Open Access

    The investigation of the chemical reactivity of metal centres in metalloproteins in aqueous solution is challenging. Here, the authors demonstrate the use of single molecule force spectroscopy to study the chemical reactivity of the iron-sulfur centre in rubredoxin in aqueous solution.

    • Peng Zheng
    • , Guilherme M. Arantes
    •  & Hongbin Li

  • Article
    | Open Access

    Carotenes are naturally abundant, widely studied unsaturated hydrocarbon pigments but their metal-binding ability has been virtually unexplored. Here, the authors demonstrate that they can be used to reversibly assemble and align homo- and hetero-metallic decanuclear chain complexes.

    • Shinnosuke Horiuchi
    • , Yuki Tachibana
    •  & Tetsuro Murahashi

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