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Metagenomics is the study of the metagenome—the collective genome of microorganisms from an environmental sample—to provide information on the microbial diversity and ecology of a specific environment. Shotgun metagenomics refers to the approach of shearing DNA extracted from the environmental sample and sequencing the small fragments.
Genome-wide association analysis in over one million individuals of European ancestry identifies 2,103 independent genetic signals (including 113 new loci) associated with blood pressure traits.
Here, the authors present a multi-omics examination of stool samples obtained from individuals with diverticulitis and controls, uncovering disruptions in the balance of microbial composition and metabolites, as well as co-occurring microbe-metabolite associations relevant to the disease.
Next-Generation Sequencing and analysis of 16 S rRNA gene from Bengali, Chakma, Marma, Khyang, and Tripura fecal samples revealed a distinct diversity profile of their gut microbiota compared to that of other countries.
Cas9 nucleases hold clinical significance for genome editing therapies. Here the authors characterize CoCas9, a compact, efficient and precise Cas9 from the human microbiome, and show that delivery via AAV vectors enables efficient editing in the mouse retina, expanding the genome editing toolbox.
Multidisciplinary culture-dependent and -independent techniques elucidate the unique microbial nitrogen cycle in nutrient-poor coastal Antarctica soils and reveal the contribution of novel key microbes to their nitrogen budget.
Metatranscriptomic data from more than 2,000 mosquitoes of 81 species show that the composition of mosquito viral communities is determined more by host phylogeny than by climate and land-use factors, which will help to inform arbovirus surveillance.
This Genome Watch highlights different tools and strategies used to enhance the quality of metagenome-assembled genomes (MAGs) generated in microbiome studies.
An experiment that simulates rainfall events in dry soils reveals that virus members of the soil microbiome maintain the turnover of prokaryotic host communities through a ‘cull-the-winner’ model.