Mesenchymal migration articles within Nature Communications

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  • Article
    | Open Access

    Focal adhesions are dynamic structures that link the cell to the extracellular matrix. Here, the authors report that focal adhesions contain tropomyosin-decorated actin filaments, and show evidence that suggests specific functions in adhesion dynamics and cell migration.

    • Reena Kumari
    • , Katharina Ven
    •  & Pekka Lappalainen

  • Article
    | Open Access

    The WAVE regulatory complex activates Arp2/3 at the cell cortex and in membrane protrusions to generate persistent cell migration. Here authors show that PPP2R1A, a scaffold subunit of protein phosphatase 2, associates with an alternative form of the WAVE complex where WAVE, the subunit that activates Arp2/3, is replaced by NHSL1.

    • Yanan Wang
    • , Giovanni Chiappetta
    •  & Alexis M. Gautreau

  • Article
    | Open Access

    The nucleus connects to the actin cytoskeleton for nuclear movement in migrating cells. Here, the authors show that the endoplasmic reticulum shields actin cables to generate asymmetric nucleo-cytoskeleton connections for nuclear positioning.

    • Cátia Silva Janota
    • , Andreia Pinto
    •  & Edgar R. Gomes

  • Article
    | Open Access

    Cell migration is essential for many physiological processes. Its deregulation causes cancer metastasis and it is not well understood how it is tightly controlled. We identify NHSL1 as a negative regulator of actin nucleating Scar/WAVE-Arp2/3 complexes, cell protrusion stability, and cell migration.

    • Ah-Lai Law
    • , Shamsinar Jalal
    •  & Matthias Krause

  • Article
    | Open Access

    Circular dorsal ruffles (CDRs) are apical actin enriched structures involved in the interpretation of growth factor gradients during cell migration. Here, the authors find that a RAB35/PI3K axis is necessary and sufficient for the formation and stabilization of polarized CDRs and persistent directional migration.

    • Salvatore Corallino
    • , Chiara Malinverno
    •  & Giorgio Scita

  • Article
    | Open Access

    Following epithelial-mesenchymal transition, avian trunk neural crest cell polarity determines directional migration but how this is established is unclear. Here, the authors find that the RhoGAP, Deleted in liver cancer 1, is asymmetrically localized in the cytoplasm, governing neural crest migratory polarization.

    • Jessica Aijia Liu
    • , Yanxia Rao
    •  & Martin Cheung

  • Article
    | Open Access

    Actin polymerization in lamellipodia of cells is regulated by the Arp2/3 complex and FMNL family formins. Here the authors show that both FMNL2 and FMNL3 contribute to lamellipodium protrusion and structure, and abolishing FMNL2/3 reduces protrusion force generation and migration, without affecting Arp2/3 incorporation.

    • Frieda Kage
    • , Moritz Winterhoff
    •  & Klemens Rottner

  • Article
    | Open Access

    Endothelial to mesenchymal transition (EndMT) is a crucial developmental process that also plays a role in the pathogenesis of some diseases. Here the authors show that EndMT contributes to the development of atherosclerosis in mice and humans, and is associated with complex human plaques that may be prone to rupture.

    • Solene M. Evrard
    • , Laura Lecce
    •  & Jason C. Kovacic

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