Membrane curvature

Membrane curvature is the deflection of cellular membranes. The generation of membrane curvature is essential for cellular processes such as cell division, and endocytosis and exocytosis. Membrane curvature can be induced by protein association with the membrane or by changes in local membrane lipid concentration.

Latest Research and Reviews

News and Comment

  • News and Views |

    Compared with most intracellular vesicles, the autophagosome is formed by an unusual event of vesicle budding involving an elusive sequence of membrane expansions that ends with a double membrane vesicle. It is now shown that actin polymerization inside the forming autophagosome is a driving force for the expansion and assembly of a functional autophagosome.

    • Petter Holland
    •  & Anne Simonsen
    Nature Cell Biology 17, 1094-1096
  • News and Views |

    Clathrin-independent endocytosis removes membrane receptors and other proteins from the cell surface, yet the mechanisms controlling this process remain unclear. Galectin-3 is now shown to regulate the biogenesis of a subpopulation of clathrin-independent carriers (CLICs). Galectin-3 binds to glycosylated cargo proteins and interacts with membrane glycosphingolipids to induce membrane deformation and CLIC formation.

    • Pamela Stanley
    Nature Cell Biology 16, 506-507
  • News and Views |

    Using in vitro reconstitution systems, three studies shed light on the interactions of Atg8 family proteins with cargo receptors and components of the basal autophagy machinery. The results have important mechanistic implications for selective macroautophagy, scaffold formation and spatio-temporal organization of the lipidation process during autophagosome formation.

    • Terje Johansen
    •  & Trond Lamark
    Nature Cell Biology 16, 395-397