Male factor infertility


Male factor infertility is the failure of a couple to conceive owing to a male-related factor. Male factor infertility can be caused by semen abnormalities (detected on semen analysis) or sexual dysfunction.

Latest Research and Reviews

  • Reviews |

    Varicocele is the most common correctable cause of male infertility, but some men with varicoceles are able to father children, even without intervention, and so the link between varicoceles and male infertility remains a matter of debate. Oxidative stress seems to be a central mechanism of testicular damage; however, no single theory to explain the differential effect of varicoceles on infertility has been suggested. In this Review, a panel of expert authors discuss the epidemiology and pathophysiology of varicocele-related infertility, and consider the optimal treatment for men with varicocele.

    • Christian Fuglesang S. Jensen
    • , Peter Østergren
    • , James M. Dupree
    • , Dana A. Ohl
    • , Jens Sønksen
    •  & Mikkel Fode
  • Reviews |

    High levels of seminal oxidative stress lead to sperm DNA damage and male factor infertility. In this review, the authors describe the mechanisms of oxidative-stress-induced male factor infertility, and how lifestyle-related interventions might reduce levels of seminal oxidative stress, ameliorate infertility and potentially improve the health of the children of men with high levels of seminal oxidative stress.

    • Shilpa Bisht
    • , Muneeb Faiq
    • , Madhuri Tolahunase
    •  & Rima Dada
  • Reviews |

    Semen quality in young men has been declining, and shows geographical, as well as temporal, variation. Several aspects of modern life, including lifestyle and environmental factors, stress, and exposure to endocrine disruptors and radiation, could be contributing to these trends. In this Review, the authors describe how semen quality is changing in the 21st century, and consider how we can best identify and avoid the underlying causes.

    • Helena E. Virtanen
    • , Niels Jørgensen
    •  & Jorma Toppari

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