Lymphopoiesis

Definition

Lymphopoiesis is the process in which lymphocytes (B cells, T cells and NK cells) develop from progenitor cells. B cell lymphopoiesis is completed in the bone marrow, whereas T cell lymphopoiesis occurs in the thymus.

Latest Research and Reviews

News and Comment

  • News and Views |

    The ability to expand and contract populations of myeloid and lymphoid cells during emergency hematopoiesis helps shape the immune response. The expression of intracellular and soluble forms of osteopontin regulates apoptosis thresholds differently in myeloid cells and lymphoid cells to counter infection.

    • Motti Gerlic
    •  & Ben A Croker
    Nature Immunology 18, 953–954
  • News and Views |

    Altered signaling via the T cell antigen receptor (TCR) promotes an adipose-tissue-like phenotype in invariant natural killer cells (iNKT cells) during thymic development and causes selective enrichment for iNKT cells in adipose tissues.

    • Jayati Mookerjee-Basu
    •  & Dietmar J Kappes
    Nature Immunology 18, 10–12
  • News and Views |

    By taking advantage of an MR1 tetramer to accurately detect mucosal-associated invariant T (MAIT) cells in both mice and humans, researchers defined the thymic development of MAIT cells.

    • Haiguang Wang
    •  & Kristin A Hogquist
    Nature Immunology 17, 1238–1240