Lymph node

Lymph nodes are small organs that are distributed throughout the body and drain lymph fluid from the tissues. Immune cells reside in lymph nodes and survey the lymph for signs of infection. If a tissue is infected, immune cells in the draining lymph node become activated and proliferate.

Latest Research and Reviews

  • Reviews |

    Turley and Krishnamurty review new insights into lymph node stromal cells, a heterogeneous cell population that serves distinct functions during development, in maintaining lymphocyte homeostasis, and in coordinating immune responses.

    • Akshay T. Krishnamurty
    •  & Shannon J. Turley
    Nature Immunology 21, 369-380
  • Research
    | Open Access

    Immune cells mostly enter lymph nodes (LN) from blood circulation, but whether afferent lymphatics contributes to LN entry is unclear. Here, the authors show, using a photo-convertible reporter, that T cells in afferent lymphatics frequently enter LN and become arrested in the subcapsular sinus, with chemokines and integrins further guiding their migration in the LN.

    • Rieke Martens
    • , Marc Permanyer
    • , Kathrin Werth
    • , Kai Yu
    • , Asolina Braun
    • , Olga Halle
    • , Stephan Halle
    • , Gwendolyn E. Patzer
    • , Berislav Bošnjak
    • , Friedemann Kiefer
    • , Anika Janssen
    • , Michaela Friedrichsen
    • , Jenny Poetzsch
    • , Karan Kohli
    • , Yvonne Lueder
    • , Rodrigo Gutierrez Jauregui
    • , Nadine Eckert
    • , Tim Worbs
    • , Melanie Galla
    •  & Reinhold Förster
  • Research
    | Open Access

    Lymphatic endothelial cells (LECs) can cross-present antigen to naïve CD8+ T cells, but the significance of this interaction was unclear. Here the authors show that LECs directly induce CD8+ T cell differentiation with memory-like phenotypes, migration patterns and transcriptome, which can later be recalled to promote effector immunity and protection from Listeria infection.

    • Efthymia Vokali
    • , Shann S. Yu
    • , Sachiko Hirosue
    • , Marcela Rinçon-Restrepo
    • , Fernanda V. Duraes
    • , Stefanie Scherer
    • , Patricia Corthésy-Henrioud
    • , Witold W. Kilarski
    • , Anna Mondino
    • , Dietmar Zehn
    • , Stéphanie Hugues
    •  & Melody A. Swartz
  • Research
    | Open Access

    Fibroblastic reticular cells (FRC) are important for lymph node (LN) structure and function. Here the authors show that the YAP/TAZ complex downstream of Hippo signalling regulates FRC commitment and maturation, with YAP/TAZ deficiency impairing FRC differentiation, while hyperactivation of YAZ/TAZ inducing myofibroblastic FRCs and LN fibrosis.

    • Sung Yong Choi
    • , Hosung Bae
    • , Sun-Hye Jeong
    • , Intae Park
    • , Hyunsoo Cho
    • , Seon Pyo Hong
    • , Da-Hye Lee
    • , Choong-kun Lee
    • , Jin-Sung Park
    • , Sang Heon Suh
    • , Jeongwoon Choi
    • , Myung Jin Yang
    • , Jeon Yeob Jang
    • , Lucas Onder
    • , Jeong Hwan Moon
    • , Han-Sin Jeong
    • , Ralf H. Adams
    • , Jin-Man Kim
    • , Burkhard Ludewig
    • , Joo-Hye Song
    • , Dae-Sik Lim
    •  & Gou Young Koh
  • Reviews |

    Nanoscale and microscale materials can be used as drug delivery vehicles to target specific lymph node-resident cell subtypes for immunotherapy. In this Review, the authors discuss the transport mechanisms to and from lymph nodes and how they can be explored for drug delivery.

    • Alex Schudel
    • , David M. Francis
    •  & Susan N. Thomas

News and Comment

  • News and Views |

    B cells undergo iterative rounds of somatic hypermutation and selection for high-affinity antigen binding in the germinal center microenvironment. Two new studies provide insights into the temporal and spatial control mechanisms that act within B cells and follicular dendritic cells to jointly govern B cell differentiation and cell traffic within the GC.

    • Jagan R. Muppidi
    •  & Ulf Klein
    Nature Immunology 21, 599-601
  • News and Views |

    The biodistribution of the components of a messenger RNA vaccine following its administration in non-human primates can be non-invasively monitored by labelling the vaccine with a dual radionuclide–near-infrared probe.

    • Sebastian Ols
    •  & Karin Loré
  • News and Views |

    The cytokine IL-17 augments metabolism in fibroblastic reticular cells in lymph nodes, which enhances their proliferation and survival to support B cell responses during autoimmunity.

    • Scott N. Mueller
    Nature Immunology 20, 524-526
  • Research Highlights |

    Lee et al. show that in a mouse model of melanoma, tumour cells that spread to the draining lymph node adapt to the fatty acid-rich environment in the lymph node by activation of YAP signalling and fatty acid oxidation.

    • Ulrike Harjes