Zhang, Hou, Xu, Srinivas et al. report the mechanism of colistin resistance imparted by MCR-4, which has a distinct catalytic domain but employs a similar ping-pong catalysis mechanism to that used by the well-studied MCR-1. This study provides further insights into the bacterial resistance to colistin, the last-resort antibiotic.
- Huimin Zhang
- Mengyun Hou
- Youjun Feng