Kidney articles within Nature

Featured

• Article | 08 December 2021

  Structural basis of inhibition of the human SGLT2–MAP17 glucose transporter

  Using cryogenic electron microscopy, the structure of the human SGLT2–MAP17 complex captured in the empagliflozin-bound state reveals the inhibitory mechanism of these anti-diabetic drugs.

  • Yange Niu
  • , Rui Liu
  •  & Lei Chen

• Article | 24 November 2021

  Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response

  Endogenous formaldehyde accumulation reveals Cockayne syndrome in mice and stimulates production of the anorexiogenic peptide GDF15 in proximal tubule cells.

  • Lee Mulderrig
  • , Juan I. Garaycoechea
  •  & Ketan J. Patel

• Article | 24 October 2018

  De novo NAD⁺ synthesis enhances mitochondrial function and improves health

  Genetic or pharmacological inhibition of α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase increases NAD⁺ and improves mitochondrial function in nematodes and mice, and may have therapeutic potential in kidney and liver disease.

  • Elena Katsyuba
  • , Adrienne Mottis
  •  & Johan Auwerx

• Letter | 03 May 2017

  Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

  The molecular mechanism of Goodpasture disease is modelled to mechanistically determine how a human leukocyte antigen (HLA) allele can exert its dominant protective effect in autoimmune disease.

  • Joshua D. Ooi
  • , Jan Petersen
  •  & A. Richard Kitching

• Letter | 16 March 2016

  PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

  PGC1α protects against kidney injury by upregulating enzymes that enhance nicotinamide adenine dinucleotide (NAD) and driving local accumulation of the fatty acid breakdown product β-hydroxybutyrate, which leads to increased production of the renoprotective prostaglandin E₂.

  • Mei T. Tran
  • , Zsuzsanna K. Zsengeller
  •  & Samir M. Parikh