Intestinal stem cells

Definition

Intestinal stem cells are multipotent adult stem cells, which in mammals reside in the base of the crypts of the adult intestine. Intestinal stem cells continuously self-renew by dividing and differentiate into the specialised cells of the intestinal epithelium, which renews throughout life.

Latest Research and Reviews

  • Research |

    Cruz-Acuña et al. develop synthetic hydrogels that support the generation and expansion of viable human intestinal organoids from pluripotent stem cells and can be used as injectable vehicles for organoid engraftment and wound healing.

    • Ricardo Cruz-Acuña
    • , Miguel Quirós
    • , Attila E. Farkas
    • , Priya H. Dedhia
    • , Sha Huang
    • , Dorothée Siuda
    • , Vicky García-Hernández
    • , Alyssa J. Miller
    • , Jason R. Spence
    • , Asma Nusrat
    •  & Andrés J. García
    Nature Cell Biology 19, 1326–1335
  • Research |

    Schell et al. demonstrate that inactivation of the mitochondrial pyruvate carrier in mouse and fly intestinal stem cells (ISCs) locks the cell into a glycolytic metabolic program and promotes the expansion of the stem cell compartment.

    • John C. Schell
    • , Dona R. Wisidagama
    • , Claire Bensard
    • , Helong Zhao
    • , Peng Wei
    • , Jason Tanner
    • , Aimee Flores
    • , Jeffrey Mohlman
    • , Lise K. Sorensen
    • , Christian S. Earl
    • , Kristofor A. Olson
    • , Ren Miao
    • , T. Cameron Waller
    • , Don Delker
    • , Priyanka Kanth
    • , Lei Jiang
    • , Ralph J. DeBerardinis
    • , Mary P. Bronner
    • , Dean Y. Li
    • , James E. Cox
    • , Heather R. Christofk
    • , William E. Lowry
    • , Carl S. Thummel
    •  & Jared Rutter
    Nature Cell Biology 19, 1027–1036
  • Research |

    R-spondin and Wnt ligand families act non-redundantly and cooperatively within the same molecular pathway in the intestinal stem-cell niche to maintain stem-cell competency and drive stem-cell expansion.

    • Kelley S. Yan
    • , Claudia Y. Janda
    • , Junlei Chang
    • , Grace X. Y. Zheng
    • , Kathryn A. Larkin
    • , Vincent C. Luca
    • , Luis A. Chia
    • , Amanda T. Mah
    • , Arnold Han
    • , Jessica M. Terry
    • , Akifumi Ootani
    • , Kelly Roelf
    • , Mark Lee
    • , Jenny Yuan
    • , Xiao Li
    • , Christopher R. Bolen
    • , Julie Wilhelmy
    • , Paige S. Davies
    • , Hiroo Ueno
    • , Richard J. von Furstenberg
    • , Phillip Belgrader
    • , Solongo B. Ziraldo
    • , Heather Ordonez
    • , Susan J. Henning
    • , Melissa H. Wong
    • , Michael P. Snyder
    • , Irving L. Weissman
    • , Aaron J. Hsueh
    • , Tarjei S. Mikkelsen
    • , K. Christopher Garcia
    •  & Calvin J. Kuo
    Nature 545, 238–242

News and Comment