Insulin signalling

Insulin signalling is initiated when secreted insulin or insulin-like growth factors bind to the plasma-membrane-localised insulin receptor. Insulin is secreted in response to increased blood glucose levels. Insulin binding to its receptor activates a cell signalling pathway that promotes glucose uptake.

Latest Research and Reviews

  • Research | | open

    Insulin resistance is associated with development of type 2 diabetes. Here the authors show that TAZ interacts with c-Jun and Tead4, inducing expression of the insulin receptor substrate 1 (IRS1) leading to increased glucose uptake in muscle, and that its activity is counteracted by statin administration.

    • Jun-Ha Hwang
    • , A Rum Kim
    • , Kyung Min Kim
    • , Jung Il Park
    • , Ho Taek Oh
    • , Sung A Moon
    • , Mi Ran Byun
    • , Hana Jeong
    • , Hyo Kyung Kim
    • , Michael B. Yaffe
    • , Eun Sook Hwang
    •  & Jeong-Ho Hong
  • Research | | open

    Impaired glucagon secretion in patients with diabetes causes hypoglycemia. Here the authors show that therapeutic concentrations of insulin inhibit alpha-cell glucagon secretion by stimulating delta-cell insulin receptor and the release of somatostatin. Blocking somatostatin secretion or action ameliorates this effect.

    • Elisa Vergari
    • , Jakob G. Knudsen
    • , Reshma Ramracheya
    • , Albert Salehi
    • , Quan Zhang
    • , Julie Adam
    • , Ingrid Wernstedt Asterholm
    • , Anna Benrick
    • , Linford J. B. Briant
    • , Margarita V. Chibalina
    • , Fiona M. Gribble
    • , Alexander Hamilton
    • , Benoit Hastoy
    • , Frank Reimann
    • , Nils J. G. Rorsman
    • , Ioannis I. Spiliotis
    • , Andrei Tarasov
    • , Yanling Wu
    • , Frances M. Ashcroft
    •  & Patrik Rorsman
  • Research | | open

    Reduced insulin-like signaling is required for C. elegans response to many environmental stressors, but how distinct outcomes are achieved is unknown. The authors show that the cytosolic sulfotransferase SSU-1 controls neurohormonal signaling via NHR-1 to specify the animals’ osmotic stress response.

    • Nicholas O. Burton
    • , Vivek K. Dwivedi
    • , Kirk B. Burkhart
    • , Rebecca E. W. Kaplan
    • , L. Ryan Baugh
    •  & H. Robert Horvitz
  • Research |

    Impaired adipocyte insulin signalling characterizes insulin resistance. Here the authors show that the hormone-sensitive lipase can sequester the glucose-responsive transcription factor ChREBP in the cytoplasm, which prevents transcription of its target ELOVL6, resulting in reduced insulin signalling.

    • Pauline Morigny
    • , Marianne Houssier
    • , Aline Mairal
    • , Claire Ghilain
    • , Etienne Mouisel
    • , Fadila Benhamed
    • , Bernard Masri
    • , Emeline Recazens
    • , Pierre-Damien Denechaud
    • , Geneviève Tavernier
    • , Sylvie Caspar-Bauguil
    • , Sam Virtue
    • , Veronika Sramkova
    • , Laurent Monbrun
    • , Anne Mazars
    • , Madjid Zanoun
    • , Sandra Guilmeau
    • , Valentin Barquissau
    • , Diane Beuzelin
    • , Sophie Bonnel
    • , Marie Marques
    • , Boris Monge-Roffarello
    • , Corinne Lefort
    • , Barbara Fielding
    • , Thierry Sulpice
    • , Arne Astrup
    • , Bernard Payrastre
    • , Justine Bertrand-Michel
    • , Emmanuelle Meugnier
    • , Laetitia Ligat
    • , Frédéric Lopez
    • , Hervé Guillou
    • , Charlotte Ling
    • , Cecilia Holm
    • , Remi Rabasa-Lhoret
    • , Wim H. M. Saris
    • , Vladimir Stich
    • , Peter Arner
    • , Mikael Rydén
    • , Cedric Moro
    • , Nathalie Viguerie
    • , Matthew Harms
    • , Stefan Hallén
    • , Antonio Vidal-Puig
    • , Hubert Vidal
    • , Catherine Postic
    •  & Dominique Langin
    Nature Metabolism 1, 133-146
  • Research | | open

    The insulin receptor plays a key role in many physiological processes, yet how insulin effects receptor signaling at the structural level remains incomplete. Here the authors present a high-resolution cryo-EM structure of a high-affinity form of the insulin-bound insulin receptor ectodomain that sheds light on the mechanism of signal transduction.

    • Felix Weis
    • , John G. Menting
    • , Mai B. Margetts
    • , Shu Jin Chan
    • , Yibin Xu
    • , Norbert Tennagels
    • , Paulus Wohlfart
    • , Thomas Langer
    • , Christoph W. Müller
    • , Matthias K. Dreyer
    •  & Michael C. Lawrence

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