Immunoediting articles within Nature

Featured

• Letter | 10 October 2018

  IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

  In human and mouse models of ovarian cancer, endoplasmic reticulum stress and the activation of the IRE1α–XBP1 pathway decreases the metabolic fitness of T cells and limits their anti-tumour functions.

  • Minkyung Song
  • , Tito A. Sandoval
  •  & Juan R. Cubillos-Ruiz

• Letter | 16 August 2017

  CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

  CMTM6 maintains PD-L1 at the plasma membrane by inhibiting its lysosome-mediated degradation and promoting its recycling.

  • Marian L. Burr
  • , Christina E. Sparbier
  •  & Mark A. Dawson

• Letter | 26 April 2017

  Tumour ischaemia by interferon-γ resembles physiological blood vessel regression

  Interferon-γ acts on tumour endothelial cells to drive vascular regression, inducing ischaemia that leads to tumour collapse.

  • Thomas Kammertoens
  • , Christian Friese
  •  & Thomas Blankenstein

• Letter | 08 February 2012

  Expression of tumour-specific antigens underlies cancer immunoediting

  This paper illustrates that immunosurveillance and immunoediting can occur in an oncogene-driven endogenous tumour model provided that the tumours carry strong neoantigens not present in the host.

  • Michel DuPage
  • , Claire Mazumdar
  •  & Tyler Jacks

• Letter | 08 February 2012

  Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting

  Exome analysis of chemical-carcinogen-induced mouse tumours provides evidence for T-cell-mediated immunoselection as a mechanism of immunoediting.

  • Hirokazu Matsushita
  • , Matthew D. Vesely
  •  & Robert D. Schreiber