Immune cell death

Definition

Immune cell death is the process by which an immune cell undergoes cell death. There are various types of cell death mediated by intracellular programmes or external factors including apoptosis, necrosis, pyroptosis and necroptosis.

Latest Research and Reviews

News and Comment

  • News and Views |

    The Streptococcus pyogenes surface M protein is a critical multifunctional virulence factor. Recent work sheds light on a new unexpected function of the M protein in activating the host inflammasome to induce macrophage cell death and promote infection.

    • Madeleine W. Cunningham
    Nature Microbiology 2, 1334–1335
  • News and Views |

    The ability to expand and contract populations of myeloid and lymphoid cells during emergency hematopoiesis helps shape the immune response. The expression of intracellular and soluble forms of osteopontin regulates apoptosis thresholds differently in myeloid cells and lymphoid cells to counter infection.

    • Motti Gerlic
    •  & Ben A Croker
    Nature Immunology 18, 953–954
  • News and Views |

    A surprising molecular mechanism underlying signal integration and programmed proliferation in adaptive immunity has been identified: the cell-cycle regulator Myc enables a lymphocyte to add up the strength of signals it receives and time its response accordingly.

    • Becca Asquith
    •  & Rob J de Boer
    Nature Immunology 18, 12–13