Hypocretin articles within Nature Communications

Featured

• Article
  21 July 2020 | Open Access

  Orexin signaling modulates synchronized excitation in the sublaterodorsal tegmental nucleus to stabilize REM sleep

  Orexin signaling is provided by diffusely distributed fibers and involved in different brain circuits that orchestrate sleep and wakefulness states. Here, the authors show that a proportion of orexin neurons project to the sublaterodorsal tegmental nucleus and exhibit rapid eye movement (REM) sleep-related actions.

  • Hui Feng
  • , Si-Yi Wen
  •  & Jun Zhang

• Article
  19 February 2019 | Open Access

  CD8⁺ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

  Autoreactive T cells are suspected to destroy hypocretin-producing neurons in narcolepsy. Here the authors detect CD8 T cells recognizing narcolepsy-related proteins in healthy individuals and in patients with narcolepsy, and show that the frequency of self-reactive CD8 T cells differs between patients and controls sharing the same HLA-II risk allele.

  • Natasja Wulff Pedersen
  • , Anja Holm
  •  & Birgitte Rahbek Kornum