HIPPO signalling

Definition

Hippo signalling is a cell signalling pathway that controls organ size. Activation of Hippo results in a series of phosphorylation events that culminate in the phosphorylation and cytoplasmic retention of a downstream transcriptional coactivator, terminating expression of Hippo-regulated genes. Hippo signalling has an important role in development and cancer.

Latest Research and Reviews

News and Comment

  • News and Views |

    The Hippo pathway responds to environmental factors including nutrient availability, cell density and substrate stiffness to regulate organ size. This pathway is now shown to also regulate antiviral defence by modulating the TBK1-mediated control of interferon production.

    • Natalia Muñoz-Wolf
    •  & Ed C. Lavelle
    Nature Cell Biology 19, 267–269
  • News and Views |

    Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1–HER3 and Hippo–YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.

    • Wei Zhuo
    •  & Yibin Kang
  • News and Views |

    The kinase AMPK, a sensor of cellular energy stress, has been shown to oppose the growth-promoting activity of YAP, the transcriptional co-activator downstream of the Hippo signalling pathway. This finding may help to explain why the antidiabetic drug metformin, for which AMPK is a key effector, is linked to cancer-protective activity.

    • Iswar K. Hariharan
    Nature Cell Biology 17, 362–363
  • News and Views |

    Hippo signalling has been associated with many important tissue functions including the regulation of organ size. In the intestinal epithelium differing functions have been proposed for the effectors of Hippo signalling, YAP and TAZ1. These are now shown to have a dual role in the intestinal epithelium, regulating both stem cell proliferation and differentiation along a specific secretory lineage.

    • Marie Le Bouteiller
    •  & Kim B. Jensen