Herpes virus

Herpesvirus is an infectious agent belonging to the virus family Herpesviridae that causes latent and lytic infections in a wide range of animals and humans. There are 8 herpesvirus types currently known to infect humans, including Herpes simplex viruses, varicella-zoster virus, Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus and human cytomegalovirus.

Latest Research and Reviews

  • Research | | open

    Here, Depledge et al. use nanopore arrays for direct RNA sequencing to profile the HSV-1 transcriptome in productively infected cells. Sequencing of individual RNAs reveals a highly complex viral transcriptome including mRNAs encoding new viral fusion proteins derived by read-through transcription.

    • Daniel P. Depledge
    • , Kalanghad Puthankalam Srinivas
    • , Tomohiko Sadaoka
    • , Devin Bready
    • , Yasuko Mori
    • , Dimitris G. Placantonakis
    • , Ian Mohr
    •  & Angus C. Wilson
  • Reviews |

    Kaposi sarcoma is a rare cancer that typically presents with multiple pigmented skin lesions, but may take an aggressive course characterised by lesion ulceration, oedema and visceral organ involvement. This Primer describes the epidemiology, clinical features, cellular mechanisms and management of the main forms of Kaposi sarcoma.

    • Ethel Cesarman
    • , Blossom Damania
    • , Susan E. Krown
    • , Jeffrey Martin
    • , Mark Bower
    •  & Denise Whitby
  • Research |

    Genome sequencing of fractionated T-, B- and natural killer cells from patients with chronic active Epstein–Barr virus (EBV) infection sheds light on the nature of the EBV-infected progenitor and suggests a link between intragenic EBV deletions and EBV-associated neoplastic proliferations.

    • Yusuke Okuno
    • , Takayuki Murata
    • , Yoshitaka Sato
    • , Hideki Muramatsu
    • , Yoshinori Ito
    • , Takahiro Watanabe
    • , Tatsuya Okuno
    • , Norihiro Murakami
    • , Kenichi Yoshida
    • , Akihisa Sawada
    • , Masami Inoue
    • , Keisei Kawa
    • , Masao Seto
    • , Koichi Ohshima
    • , Yuichi Shiraishi
    • , Kenichi Chiba
    • , Hiroko Tanaka
    • , Satoru Miyano
    • , Yohei Narita
    • , Masahiro Yoshida
    • , Fumi Goshima
    • , Jun-ichi Kawada
    • , Tetsuya Nishida
    • , Hitoshi Kiyoi
    • , Seiichi Kato
    • , Shigeo Nakamura
    • , Satoko Morishima
    • , Tetsushi Yoshikawa
    • , Shigeyoshi Fujiwara
    • , Norio Shimizu
    • , Yasushi Isobe
    • , Masaaki Noguchi
    • , Atsushi Kikuta
    • , Keiji Iwatsuki
    • , Yoshiyuki Takahashi
    • , Seiji Kojima
    • , Seishi Ogawa
    •  & Hiroshi Kimura
    Nature Microbiology 4, 404-413
  • Research | | open

    The human genome includes a large amount of repetitive sequence, such as human satellite II (HSATII), but their function remains largely unknown. Here, Nogalski et al. show that herpesvirus infection induces HSATII RNA expression, which in turn affects virus replication and cell motility.

    • Maciej T. Nogalski
    • , Alexander Solovyov
    • , Anupriya S. Kulkarni
    • , Niyati Desai
    • , Adam Oberstein
    • , Arnold J. Levine
    • , David T. Ting
    • , Thomas Shenk
    •  & Benjamin D. Greenbaum

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