Germinal centres

Germinal centres are specialized structures that are found in the follicles of secondary lymphoid tissues. Here, B cells are stimulated by antigen and T-helper cells to undergo maturation, leading to the generation of memory B cells and plasma cells that produce high-affinity antibodies.

Latest Research and Reviews

  • Research |

    Germinal center B cells undergo reiterative rounds of proliferation and selection. Melnick and colleagues show that the histone demethylase LSD1 is necessary for this reiterative process via its interactions with the transcription factor BCL6.

    • Katerina Hatzi
    • , Huimin Geng
    • , Ashley S. Doane
    • , Cem Meydan
    • , Reed LaRiviere
    • , Mariano Cardenas
    • , Cihangir Duy
    • , Hao Shen
    • , Maria Nieves Calvo Vidal
    • , Timour Baslan
    • , Helai P. Mohammad
    • , Ryan G. Kruger
    • , Rita Shaknovich
    • , Ann M. Haberman
    • , Giorgio Inghirami
    • , Scott W. Lowe
    •  & Ari M. Melnick
    Nature Immunology 20, 86-96
  • Research | | open

    During chronic infection CD4+ T cells can progressively acquire IL-10 producing functionality. Here the authors use single cell RNA sequencing to interrogate the IL10 CD4+ T cell compartment in a murine model of chronic infection and identify Il10-producing Tfh involved in promotion of the antiviral humoral immune response.

    • Gang Xin
    • , Ryan Zander
    • , David M. Schauder
    • , Yao Chen
    • , Jason S. Weinstein
    • , William R. Drobyski
    • , Vera Tarakanova
    • , Joseph Craft
    •  & Weiguo Cui
  • Research |

    Patients who express a hyperactive mutant of the kinase PI3K exhibit defective humoral immunity. Preite et al. show that overactive PI3K leads to defective class-switched antigen-specific responses to immunization, despite augmented germinal-center formation and reactivity to commensal microbes and self antigens.

    • Silvia Preite
    • , Jennifer L. Cannons
    • , Andrea J. Radtke
    • , Ivan Vujkovic-Cvijin
    • , Julio Gomez-Rodriguez
    • , Stefano Volpi
    • , Bonnie Huang
    • , Jun Cheng
    • , Nicholas Collins
    • , Julie Reilley
    • , Robin Handon
    • , Kerry Dobbs
    • , Lutfi Huq
    • , Indu Raman
    • , Chengsong Zhu
    • , Quan-Zhen Li
    • , Ming O. Li
    • , Stefania Pittaluga
    • , Gulbu Uzel
    • , Luigi D. Notarangelo
    • , Yasmine Belkaid
    • , Ronald N. Germain
    •  & Pamela L. Schwartzberg
    Nature Immunology 19, 986-1000
  • Research |

    Human follicular lymphomas arise from germinal center B cells. Milpied and colleagues use single-cell transcriptomic analysis to show that follicular lymphoma cells lose synchronized gene-expression patterns that characterize normal germinal center B cells.

    • Pierre Milpied
    • , Iñaki Cervera-Marzal
    • , Marie-Laure Mollichella
    • , Bruno Tesson
    • , Gabriel Brisou
    • , Alexandra Traverse-Glehen
    • , Gilles Salles
    • , Lionel Spinelli
    •  & Bertrand Nadel
    Nature Immunology 19, 1013-1024
  • Research | | open

    In the germinal center (GC), B and T cells interact to induce the production of protective antibodies against threats. Here the authors show that microRNA miR-146a modulates CD40 signaling in GC B cells, while both miR-146a and miR-146b synergize to control GC T cell responses, thereby implicating intricate controls of GC response by miR-146.

    • Sunglim Cho
    • , Hyang-Mi Lee
    • , I-Shing Yu
    • , Youn Soo Choi
    • , Hsi-Yuan Huang
    • , Somaye Sadat Hashemifar
    • , Ling-Li Lin
    • , Mei-Chi Chen
    • , Nikita D. Afanasiev
    • , Aly Azeem Khan
    • , Shu-Wha Lin
    • , Alexander Y. Rudensky
    • , Shane Crotty
    •  & Li-Fan Lu

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