Genetic vectors articles within Nature

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  • Article
    | Open Access

    In situ spatial transcriptomic analysis of more than 1 million cells are used to create a 200-nm-resolution spatial molecular atlas of the adult mouse central nervous system and identify previously unknown tissue architectures.

    • Hailing Shi
    • , Yichun He
    •  & Xiao Wang
  • Article |

    The feasibility of adeno-associated-virus-delivered nonsense suppressor tRNAs operating on premature termination codons (AAV-NoSTOP) is explored to restore gene function, using a mouse model of mucopolysaccharidosis type I for proof of concept.

    • Jiaming Wang
    • , Yue Zhang
    •  & Dan Wang
  • Article |

    A programmable transposase integrates donor DNA at user-defined genomic target sites with high fidelity, revealing a new approach for genetic engineering that obviates the need for DNA double-strand breaks and homologous recombination. 

    • Sanne E. Klompe
    • , Phuc L. H. Vo
    •  & Samuel H. Sternberg